Akinyele may refer to:
- Akinyele (rapper) (born 1971), American rapper
- Akinyele, Oyo State, in Nigeria
- Alexander Akinyele (1875–1968), Nigerian clergyman
- Isaac Babalola Akinyele (1882–1964), Nigerian king
- Theophilus Adeleke Akinyele (1932–2020), Nigerian civil servant
- Akinyele Umoja (born 1954), American academic and activist