Akkermansia is a genus in the phylum Verrucomicrobiota (Bacteria).[2] The genus was first proposed by Derrien et al. (2004), with the type species Akkermansia muciniphila (gen. nov., sp. nov).[1]
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| Genus: | Akkermansia Derrien et al. 2004[1]
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| Akkermansia muciniphila Derrien et al. 2004
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Until 2016 the genus contained a single known species, namely A. muciniphila.[2] In 2016, Akkermansia glycaniphila was isolated in the feces of a reticulated python.[3]
Etymology
editThe name Akkermansia (Ak.ker.man'si.a.) derives from: Neo-Latin feminine gender noun Akkermansia, named after Anton Dirk Louis Akkermans (28 October 1940 – 21 August 2006),[4] a Dutch microbiologist recognized for his contribution to microbial ecology.[2] Neo-Latin neuter gender noun mucinum, mucin; Neo-Latin adjective philus from Greek adjective philos (φίλος) meaning friend, loving; Neo-Latin feminine gender adjective muciniphila, mucin-loving).[1]
Description
editCells are oval-shaped, non-motile and stain Gram-negative. Strictly anaerobic organism. Chemo-organotrophic. Mucolytic in pure culture.[1]: 1474
Phylogeny
editThe currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN)[2] and National Center for Biotechnology Information (NCBI)[5]
| 16S rRNA based LTP_08_2023[6][7][8] | 120 marker proteins based GTDB 08-RS214[9][10][11] | ||||||||||||||||||||||||||||||||||||
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Human metabolism
editAkkermansia muciniphila can reside in the human intestinal tract and is currently being studied for its effects on human metabolism and health.[12] It could be of interest for the treatment of obesity and type 2 diabetes. Akkermansia has been shown to reverse high-fat diet-induced metabolic disorders in mice by increasing intestinal levels of endocannabinoids (e.g. 2-arachidonoylglycerol and 2-oleoylglycerol) and mucosal thickness.[13][14][15] Another study showed that Akkermansia muciniphil alleviates depression-like behavior by regulating gut microbiota and metabolites in a chronic stress mouse model.[16]
See also
editReferences
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- ^ a b c d Derrien M, Vaughan EE, Plugge CM, de Vos WM (September 2004). "Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium". International Journal of Systematic and Evolutionary Microbiology. 54 (Pt 5): 1469–1476. doi:10.1099/ijs.0.02873-0. PMID 15388697.
- ^ a b c d e "Genus: Akkermansia". List of Prokaryotic names with Standing in Nomenclature (LPSN). Leibniz Institute DSMZ. Retrieved 2023-12-20.
- ^ Ouwerkerk JP, Aalvink S, Belzer C, de Vos WM (November 2016). "Akkermansia glycaniphila sp. nov., an anaerobic mucin-degrading bacterium isolated from reticulated python faeces". International Journal of Systematic and Evolutionary Microbiology. 66 (11): 4614–4620. doi:10.1099/ijsem.0.001399. PMID 27499019.
- ^ In memory of Antonius Dirk Louis (Anton) Akkermans, Springer Reference, retrieved 30 April 2014
- ^ "Akkermansia". National Center for Biotechnology Information (NCBI) taxonomy database. Retrieved 2022-09-09.
- ^ "The LTP". Retrieved 20 November 2023.
- ^ "LTP_all tree in newick format". Retrieved 20 November 2023.
- ^ "LTP_08_2023 Release Notes" (PDF). Retrieved 20 November 2023.
- ^ "GTDB release 08-RS214". Genome Taxonomy Database. Retrieved 10 May 2023.
- ^ "bac120_r214.sp_label". Genome Taxonomy Database. Retrieved 10 May 2023.
- ^ "Taxon History". Genome Taxonomy Database. Retrieved 10 May 2023.
- ^ Jayachandran M, Chung SS, Xu B (2020). "A critical review of the relationship between dietary components, the gut microbe Akkermansia muciniphila, and human health". Critical Reviews in Food Science and Nutrition. 60 (13): 2265–2276. doi:10.1080/10408398.2019.1632789. PMID 31257904. S2CID 195759418.
- ^ Lyte M, Cryan J, eds. (2014). Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease. Advances in Experimental Medicine and Biology. Vol. 817. New York, NY: Springer New York. doi:10.1007/978-1-4939-0897-4. ISBN 978-1-4939-0896-7.
- ^ Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, et al. (May 2013). "Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity". Proceedings of the National Academy of Sciences of the United States of America. 110 (22): 9066–9071. doi:10.1073/pnas.1219451110. PMC 3670398. PMID 23671105.
- ^ Tripathi AK, Kotak M, eds. (2022). Gut Microbiome in Neurological Health and Disorders. Nutritional Neurosciences. Singapore: Springer Nature Singapore. doi:10.1007/978-981-19-4530-4. ISBN 978-981-19-4529-8.
- ^ Ding Y, Bu F, Chen T, Shi G, Yuan X, Feng Z, et al. (November 2021). "A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress-induced depressive-like behavior in mice by regulating gut microbiota and metabolites". Applied Microbiology and Biotechnology. 105 (21–22): 8411–8426. doi:10.1007/s00253-021-11622-2. PMID 34617139.