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Alain Manceau

Alain Manceau, born September 19, 1955, is a French environmental mineralogist and biogeochemist. He is known for his research on the structure and reactivity of nanoparticulate iron and manganese oxides and clay minerals, on the crystal chemistry of strategic metals and rare-earth elements, and on the structural biogeochemistry of mercury in natural systems, animals, and humans.

Alain Manceau
c. 2015
Born (1955-09-19) September 19, 1955 (age 69)
Valmondois, France
Alma materÉcole Normale Supérieure de Saint-Cloud, today ENS-Lyon
University Paris VII, today Université Paris Cité
AwardsCNRS Bronze Medal
CNRS Silver Medal
ES&T Best Paper Award
Prix Léon Lutaud, Georges Millot medal Académie des sciences (France)
Scientific career
FieldsMineralogy, Biogeochemistry
InstitutionsFrench National Centre for Scientific Research (CNRS)
IMPMC, Paris
ISTerre, Grenoble
ENS-Lyon, Lyon
ESRF, Grenoble
Doctoral advisorGeorges Calas
Websiteperso.ens-lyon.fr/alain.manceau/

Biography

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Manceau is a former pupil of the École Saint-Martin-de-France in Pontoise, then of the Lycée Henri IV in Paris where he completed his preparatory classes before entering the École Normale Supérieure de Saint-Cloud (now École Normale Supérieure de Lyon) in 1977.[1] He obtained the agrégation in natural sciences in 1981, then his doctorate in 1984 at the University Paris VII (now Université Paris Cité) under the direction of George Calas.[2] He spent his entire academic career at the French National Centre for Scientific Research (CNRS), first as a research fellow from 1984, then as a research director from 1993 to 2022.[1] From 1984 to 1992, he worked at the Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie (IMPMC) in Paris,[3] and from 1993 to 2022 at the Institut des Sciences de la Terre (ISTerre) of the Grenoble Alpes University. He was appointed emeritus CNRS Researcher at the ENS-Lyon in 2022,[4] and research scientist at the European Synchrotron Radiation Facility (ESRF) in 2023.[5] In 1997, he was a visiting professor at the University of Illinois Urbana-Champaign, then Adjunct professor until 2001.[1] He was a visiting professor at the University of California, Berkeley from 2001 to 2002.[1]

Scientific works

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Environmental mineralogy and geochemistry

Minerals play a key role in the biogeochemical cycling of the elements at the Earth's surface, sequestering and releasing them as they undergo precipitation, crystal growth, and dissolution in response to chemical and biological processes. Manceau's research in this field focuses on the structure of disordered minerals (clays, iron (Fe) and manganese (Mn) oxides, including ferrihydrite and birnessite), on chemical reactions at their surface in contact with aqueous solutions, and on the crystal chemistry of trace metals in these phases.

In 1993, he established in collaboration with Victor Drits a structural model for ferrihydrite based on the modeling of the X-ray diffraction pattern.[6] This model was confirmed in 2002 by Rietveld refinement of the neutron diffraction pattern,[7] and in 2014 by simulation of the pair distribution function measured by high-energy X-ray scattering.[8]

 
Electron image of δ-MnO2 nanoparticles viewed parallel (a) and perpendicular (b) to the layer plane.[8]
 
Structure of a cylindrically bent layer of δ-MnO2 nanosheet.[8]

In 1997, he and Victor Drits led the synthesis and resolution of the structure of hexagonal and monoclinic birnessite, and they showed in 2002 that the monoclinic form possesses a triclinic distortion.[9][10][11] The hexagonal form prevails at the Earth's surface and owes its strong chemical reactivity to the existence of heterovalent Mn4+-Mn3+-Mn2+ substitutions and Mn4+ vacancies in the MnO2 layer. The Mn4+-Mn3+ and Mn3+-Mn2+ redox couples confer to this material oxidation-reduction properties used in catalysis, electrochemistry, and in the electron transfer during the photo-dissociation of water by photosystem II,[12] while the vacancies are privileged sites for the adsorption of cations. He has characterized and modeled a number of chemical reactions occurring at the birnessite-water interface, including those of complexation of transition metals (Ni, Cu, Zn, Pb, Cd...), and oxidation of As3+ to As5+, Co2+ to Co3+,[13][14] and Tl+ to Tl3+.[15] The oxidative uptake of cobalt on birnessite leads to its billion-fold enrichment in marine ferromanganese deposits compared to seawater.[16]

From 2002 to 2012, he applied the knowledge base acquired on the crystal chemistry of trace metals and biogeochemical processes at mineral surfaces and the root-soil interface (rhizosphere) to the phytoremediation of contaminated soils and sediments, and abandoned mine sites.[17][18][19] He contributed to improving the Jardins Filtrants® (Filtering Gardens) process for treating wastewater and solid matrices by phytolixiviation, phytoextraction, and rhizofiltration developed by the Phytorestore company.

In 2022, he extended his research on the crystal chemistry of trace metals to processes responsible for the 106 to 109 times enrichment of strategic rare-earth elements (REE) and redox-sensitive elements (cerium, thallium, platinum) in marine deposits relative to seawater. REE are associated with fluorapatite in marine sediments,[20] whereas redox metals are oxidatively scavenged by birnessite in manganese nodules and crusts.[21]

Structural biogeochemistry of mercury

 
Binding site of mercury (Hg) in selenoprotein P of grebe bird.[22][23]

Mercury (Hg) is a global pollutant that is generated both by natural sources, such as volcanic eruptions and wildfires, and human activities, such as coal combustion, gold mining, and the incineration of industrial waste. In aquatic and terrestrial food chains, mercury accumulates as methylmercury (MeHg), a potent toxin that affects the function of animal's and human's brain and reproductive system. Understanding the internal detoxification processes of MeHg in living organisms is essential for protecting wildlife and humans, and designing treatments against mercury poisoning.

In 2015, Manceau led foundational studies on the structural biogeochemistry of mercury in bacteria, plants, animals, and humans using X-ray emission spectroscopy at the ESRF. In 2021, he found that the Clark's grebe (Aechmophorus clarkii) and the Forster's tern (Sterna forsteri) from California, the southern giant petrel (Macronectes giganteus) and the south polar skua (Stercorarius maccormicki) from the Southern Ocean, and the Indo-Pacific blue marlin (Makaira mazera) from French Polynesia, detoxify the organic methylmercury-cysteine complex (MeHgCys) in inorganic mercury-selenocysteine complex (Hg(Sec)4).[22][23][24][25] A few months later, he extended this result to long-finned pilot whale from the analysis of 89 tissues (liver, kidney, muscle, heart, brain) from 28 individuals stranded on the coasts of Scotland and the Faroe Islands.[26]

This body of work shed light on how birds, cetacea, and fishes manage to get rid of methylmercury toxicity. Demethylation of the MeHgCys complex to Hg(Sec)4 and very poorly soluble inorganic HgSe is catalyzed by selenoprotein P (SelP) within which nucleate clusters of Hgx(Sec,Se)y that grow, likely by self-assembly of mercurial proteins as is common in biomineralization processes, to form in fine inert, non-toxic mercury selenide (HgSe) crystals.

The new Hg(Sec)4 species identified by Manceau and his collaborators was the main “missing intermediate” in the chemical reaction that helps animals to survive high levels of mercury. However, because Hg(Sec)4 has a molar ratio of selenium to mercury of 4:1, four selenium atoms are required to detoxify just one mercury atom. Thus, Hg(Sec)4 severely depletes the amount of bioavailable selenium. Selenium deficiency can affect the function of animals’ brain and reproductive system, as selenoproteins serve critical antioxidant functions in the brain and testes.[27] His works on the Hg-Se antagonism won him the ES&T 2021 Best Paper Award.

The stepwise MeHgCys → Hg(Sec)4 + HgSe demethylation reaction is accompanied by the fractionation of the 202Hg and 198Hg isotopes, denoted δ202Hg. The δ202Hg fractionation measured on whole animal tissues (δ202Hgt) is the sum of the fractionations of the MeHgCys, Hg(Sec)4, and HgSe species, weighted by their relative abundance:


               δ202Hgt =   f(Spi)t × δ202Spi

where δ202Spi is the fractionation of each chemical species, and f(Spi) their relative abundance, or mole fraction. Manceau and his co-authors found that δ202Spi can be obtained by mathematical inversion of macroscopic isotopic and microscopic spectroscopic data.[26][28]

The combination of isotopic and spectroscopic data on birds and cetacea revealed that dietary methylmercury and the Hg(Sec)4-SelP complex are distributed to all tissues (liver, kidney, sketetal muscle, brain) via the circulatory system with, however, a hierarchy in the tissular percentage of each species. Most of the detoxification process is carried out in the liver, whereas the brain, which is particularly sensitive to the neurotoxic effects of mercury, is distinguished from other tissues by a low mercury concentration and a high proportion of inert HgSe. These results appear to be transposable to humans.[29]

Publications

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Manceau has published more than 200 scientific papers in Science Citation Index journals totalizing more than 24,000 citations and garnering an h-index over 90.[30] In 2020, he was ranked 111th out of a total of 70,197 researchers in Geochemistry/Geophysics in a bibliometric study by scientists of the Stanford University based on the Elsevier Scopus database.[31]

Awards and honors

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Online conference and research highlight

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References

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  1. ^ a b c d "Alain Manceau | Curriculum Vitae". Retrieved 2023-11-20.
  2. ^ "Alain Manceau | Ph.D. supervisor" (PDF). Retrieved 2023-11-20.
  3. ^ "Alain Manceau |IMPMC" (PDF). Retrieved 2023-11-20.
  4. ^ "Alain Manceau |ENS Lyon". Retrieved 2023-11-20.
  5. ^ "Alain Manceau | ESRF". 4 April 2023. Retrieved 2023-11-20.
  6. ^ Drits, V. A.; Sakharov, B. A.; Salyn, A. L.; Manceau, A. (1993). "Structural Model for Ferrihydrite". Clay Minerals. 28 (2): 185–207. Bibcode:1993ClMin..28..185D. doi:10.1180/claymin.1993.028.2.02. S2CID 11345105.
  7. ^ Jansen, E.; Kyek, A.; Schafer, W.; Schwertmann, U. (2002). "The structure of six-line ferrihydrite". Applied Physics A: Materials Science & Processing. 74: s1004–s1006. Bibcode:2002ApPhA..74S1004J. doi:10.1007/s003390101175. S2CID 55727756.
  8. ^ a b c Manceau, Alain; Marcus, Matthew A.; Grangeon, S.; Lanson, M.; Lanson, B.; Gaillot, A.-C.; Skanthakumar, S.; Soderholm, L. (2013). "Short-range and long-range order of phyllomanganate nanoparticles determined using high-energy X-ray scattering". Journal of Applied Crystallography. 46: 193–209. doi:10.1107/s0021889812047917. S2CID 56356250.
  9. ^ Drits, Victor A.; Silvester, Ewen; Gorshkov, Anatoli I.; Manceau, Alain (1997). "Structure of synthetic monoclinic Na-rich birnessite and hexagonal birnessite; I, Results from X-ray diffraction and selected-area electron diffraction". American Mineralogist. 82 (9–10): 946–961. Bibcode:1997AmMin..82..946D. doi:10.2138/am-1997-9-1012. S2CID 56030552.
  10. ^ Silvester, Ewen; Manceau, Alain; Drits, Victor A. (1997). "Structure of synthetic monoclinic Na-rich birnessite and hexagonal birnessite; II, Results from chemical studies and EXAFS spectroscopy". American Mineralogist. 82 (9–10): 962–978. Bibcode:1997AmMin..82..962S. doi:10.2138/am-1997-9-1013. S2CID 55969753.
  11. ^ Lanson, Bruno; Drits, Victor A.; Feng, Qi; Manceau, Alain (2002). "Structure of synthetic Na-birnessite: Evidence for a triclinic one-layer unit cell". American Mineralogist. 87 (11–12): 1662–1671. Bibcode:2002AmMin..87.1662L. doi:10.2138/am-2002-11-1215. S2CID 53443294.
  12. ^ Chernev, Petko; Fischer, Sophie; Hoffmann, Jutta; Oliver, Nicholas; Assunção, Ricardo; Yu, Boram; Burnap, Robert L.; Zaharieva, Ivelina; Nürnberg, Dennis J.; Haumann, Michael; Dau, Holger (2021). "Publisher Correction: Light-driven formation of manganese oxide by today's photosystem II supports evolutionarily ancient manganese-oxidizing photosynthesis". Nature Communications. 12 (1): 419. doi:10.1038/s41467-020-20868-9. PMC 7804171. PMID 33436628.
  13. ^ Manceau, Alain; Drits, Victor A.; Silvester, Ewen; Bartoli, Celine; Lanson, Bruno (1997). "Structural mechanism of Co2+ oxidation by the phyllomanganate buserite". American Mineralogist. 82: 1150–1175. doi:10.2138/am-1997-11-1213. S2CID 54923713.
  14. ^ Manceau, Alain.; Steinmann, Stephan (2022). "Density functional theory modeling of the oxidation mechanism of Co(II) by birnessite". ACS Earth and Space Chemistry. 6 (8): 2063–2075. Bibcode:2022ESC.....6.2063M. doi:10.1021/acsearthspacechem.2c00122. S2CID 251086409.
  15. ^ Manceau, Alain.; Steinmann, Stephan (2023). "Density functional theory modeling of the oxidation mechanism of Tl(I) by birnessite". ACS Earth and Space Chemistry. 7 (7): 1459–1466. Bibcode:2023ESC.....7.1459M. doi:10.1021/acsearthspacechem.3c00103. S2CID 259292146.
  16. ^ Hein, J.R.; Koschinsky, A. (2014), "Deep-Ocean Ferromanganese Crusts and Nodules", Treatise on Geochemistry, Elsevier, pp. 273–291, doi:10.1016/b978-0-08-095975-7.01111-6, ISBN 9780080983004
  17. ^ Manceau, A.; Marcus, M. A.; Tamura, N. (2002). "Quantitative Speciation of Heavy Metals in Soils and Sediments by Synchrotron X-ray Techniques". Reviews in Mineralogy and Geochemistry. 49 (1): 341–428. Bibcode:2002RvMG...49..341M. doi:10.2138/gsrmg.49.1.341.
  18. ^ Mench, Michel; Bussière, Sylvie; Boisson, Jolanda; Castaing, Emmanuelle; Vangronsveld, Jaco; Ruttens, Ann; De Koe, Tjarda; Bleeker, Petra; Assunção, Ana; Manceau, Alain (2003). "Progress in remediation and revegetation of the barren Jales gold mine spoil after in situ inactivation". Plant and Soil. 249: 187–202. doi:10.1023/a:1022566431272. S2CID 1771467.
  19. ^ Manceau, Alain; Boisset, Marie-Claire; Sarret, Géraldine; Hazemann, Jean-Louis; Mench, Michel; Cambier, Philippe; Prost, René (1996). "Direct determination of lead speciation in contaminated soils by EXAFS spectroscopy". Environmental Science & Technology. 30 (5): 1540–1552. Bibcode:1996EnST...30.1540M. doi:10.1021/es9505154.
  20. ^ Manceau, Alain; Paul, Sophie A.L.; Simionovici, Alexandre; Magnin, Valérie; Balvay, Mélanie; Findling, Nathaniel; Rovezzi, Mauro; Muller, Samuel; Barbe-Schönberg, Dieter; Koschinsky, Andrea (2022). "Fossil bioapatites with extremely high concentrations of rare earth elements and yttrium from deep-sea pelagic sediments". ACS Earth and Space Chemistry. 6 (8): 2093–2103. Bibcode:2022ESC.....6.2093M. doi:10.1021/acsearthspacechem.2c00169. S2CID 250572338.
  21. ^ Manceau, Alain; Simionovici, Alexandre; Findling, Nathaniel; Glatzel, Pieter; Detlefs, Blanka; Wegorzewki, Anna V.; Mizell, Kira; Hein, James R.; Koschinsky, Andrea (2022). "Crystal chemistry of thallium in marine ferromanganese deposits". ACS Earth and Space Chemistry. 6 (5): 1269–1285. Bibcode:2022ESC.....6.1269M. doi:10.1021/acsearthspacechem.1c00447.
  22. ^ a b Manceau, Alain; Bourdineaud, Jean-Paul; Oliveira, Ricardo B.; Sarrazin, Sandra L.F.; Krabbenhoft, David P.; Eagles-Smith, Collin A.; Ackerman, Joshua T.; Stewart, A. Robin; Ward-Deitrich, Christian; del Castillo Busto, M. Estela; Goenaga-Infante, Heidi (2021). "Demethylation of Methylmercury in Bird, Fish, and Earthworm". Environmental Science & Technology. 55 (3): 1527–1534. Bibcode:2021EnST...55.1527M. doi:10.1021/acs.est.0c04948. PMID 33476127. S2CID 231679875.
  23. ^ a b Manceau, Alain; Gaillot, Anne-Claire; Glatzel, Pieter; Cherel, Yves; Bustamante, Paco (2021). "In Vivo Formation of HgSe Nanoparticles and Hg–Tetraselenolate Complex from Methylmercury in Seabirds—Implications for the Hg–Se Antagonism". Environmental Science & Technology. 55 (3): 1515–1526. Bibcode:2021EnST...55.1515M. doi:10.1021/acs.est.0c06269. PMID 33476140. S2CID 231680173.
  24. ^ Manceau, Alain; Azemard, Sabine; Hédouin, Laetitia; Vassileva, Emilia; Lecchini, David; Fauvelot, Cécile; Swarzenski, Peter W.; Glatzel, Pieter; Bustamante, Paco; Metian, Marc (2021). "Chemical Forms of Mercury in Blue Marlin Billfish: Implications for Human Exposure". Environmental Science & Technology Letters. 8 (5): 405–411. Bibcode:2021EnSTL...8..405M. doi:10.1021/acs.estlett.1c00217. S2CID 234874204.
  25. ^ Poulin, Brett A.; Janssen, Sarah E.; Rosera, Tylor J.; Krabbenhoft, David P.; Eagles-Smith, Collin A.; Ackerman, Joshua T.; Stewart, A. Robin; Kim, Eunhee; Baumann, Zofia; Kim, Jeong-Hoon; Manceau, Alain (2021). "Isotope Fractionation from In Vivo Methylmercury Detoxification in Waterbirds". ACS Earth and Space Chemistry. 5 (5): 990–997. Bibcode:2021ESC.....5..990P. doi:10.1021/acsearthspacechem.1c00051. S2CID 233601869.
  26. ^ a b Manceau, Alain; Brossier, Romain; Poulin, Brett A. (2021). "Chemical Forms of Mercury in Pilot Whales Determined from Species-Averaged Mercury Isotope Signatures". ACS Earth and Space Chemistry. 5 (6): 1591–1599. Bibcode:2021ESC.....5.1591M. doi:10.1021/acsearthspacechem.1c00082. S2CID 236302944.
  27. ^ Burk, Raymond F.; Hill, Kristina E. (2015). "Regulation of Selenium Metabolism and Transport". Annual Review of Nutrition. 35: 109–134. doi:10.1146/annurev-nutr-071714-034250. PMID 25974694.
  28. ^ Manceau, Alain; Brossier, Romain; Janssen, Sarah E.; Rosera, Tylor J.; Krabbenhoft, David P.; Cherel, Yves; Bustamante, Paco; Poulin, Brett A. (2021). "Mercury Isotope fractionation by internal demethylation and biomineralization reactions in seabirds: Implications for environmental mercury science". Environmental Science & Technology. 55 (20): 13942–13952. Bibcode:2021EnST...5513942M. doi:10.1021/acs.est.1c04388. PMID 34596385. S2CID 238238141.
  29. ^ Korbas, Malgorzata; O’Donoghue, John L.; Watson, Gene E.; Pickering, Ingrid J.; Singh, Satya P.; Myers, Gary J.; Clarkson, Thomas W.; George, Graham N. (2010). "The Chemical Nature of Mercury in Human Brain Following Poisoning or Environmental Exposure". ACS Chemical Neuroscience. 1 (12): 810–818. doi:10.1021/cn1000765. PMC 3400271. PMID 22826746.
  30. ^ "h-index".
  31. ^ Ioannidis, John P. A.; Boyack, Kevin W.; Baas, Jeroen (2020). "Updated science-wide author databases of standardized citation indicators". PLOS Biology. 18 (10): e3000918. doi:10.1371/journal.pbio.3000918. PMC 7567353. PMID 33064726.
  32. ^ "List of MSA fellows".
  33. ^ "Recipients of the George W. Brindley Clay Science Lecture award".
  34. ^ "Recipients of the George Brown Lecture award".
  35. ^ "Equipex projects at ESRF".
  36. ^ "Academy of Europe: Manceau Alain". www.ae-info.org.
  37. ^ "List of ERC Grantees at ESRF".
  38. ^ Zimmerman, Julie Beth; Field, Jennifer; Leusch, Frederic; Lowry, Greg; Mills, Margaret; Wang, Peng; Westerhoff, Paul (15 November 2022). "The 2021 ES&T Best Paper Awards: Nevertheless, We Persisted". Environmental Science & Technology. 56 (22): 15179–15181. Bibcode:2022EnST...5615179Z. doi:10.1021/acs.est.2c07931. ISSN 0013-936X.
  39. ^ "Prix thématiques de l'Académie des Sciences, relatifs aux Sciences de l'univers".
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