Alan Garen was an American geneticist who co-discovered suppressor mutations for tRNA. The Garen lab also showed that certain triplet codons (5'-UAG, 5'-UAA, and 5'-UGA) failed to bind amino acids.[1] Thus, the Garen lab and Brenner labs are both credited with discovery of the stop codons of the genetic code.[2]
Alan Garen | |
|---|---|
| Born | March 26, 1926 United States |
| Died | April 20, 2022 (aged 96) New Haven, Connecticut, U.S. |
| Education | University of Colorado |
| Known for | Discovery of stop codons |
| Scientific career | |
| Fields | Genetics |
| Institutions | Yale University |
| Doctoral advisor | Theodore T. Puck |
Garen was a professor at Yale University between 1963 and 2021.[3] He was a member of the National Academy of Sciences and the American Academy of Arts and Sciences.
References
edit- ^ Weigert M, Galluci E, Lanka E, Garen A (1966). "Characteristics of the genetic code in vivo". Cold Spring Harb Symp Quant Biol. 31: 145–150. doi:10.1101/sqb.1966.031.01.022. PMID 4866371.
- ^ Stretton AO, Kaplan S, Brenner S (1966). "Nonsense codons". Cold Spring Harb Symp Quant Biol. 31: 173–179. doi:10.1101/sqb.1966.031.01.025. PMID 5237189.
- ^ "MB&B bids farewell to Tom Pollard and Alan Garen | Molecular Biophysics and Biochemistry".
External links
edit- Garen's webpage at Yale's Dept. of Molecular Biophysics and Biochemistry
- Academic genealogy of Alan Garen
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