Albaconazole

Albaconazole
Clinical data
ATC code	none;
Identifiers
	IUPAC name 7-Chloro-3-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]quinazolin-4-one;
CAS Number	187949-02-6 ;
PubChem CID	208952;
ChemSpider	181045 ;
UNII	YDW24Y8IAB;
KEGG	D09702 ;
ChEMBL	ChEMBL298817 ;
CompTox Dashboard (EPA)	DTXSID3058244 ;
ECHA InfoCard	100.170.829
Chemical and physical data
Formula	C20H16ClF2N5O2
Molar mass	431.83 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Fc1ccc(c(F)c1)[C@](O)([C@H](N3\C=N/c2cc(Cl)ccc2C3=O)C)Cn4ncnc4;
	InChI InChI=1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1 ; Key:UHIXWHUVLCAJQL-MPBGBICISA-N ;
	(verify)

Albaconazole (development code UR-9825) is an experimental triazole antifungal.^[1] It has potential broad-spectrum activity. The drug blocks a number of CYP450 liver enzymes.^{[citation needed]}

It has also been studied as an antiprotozoal agent.^[2]

References

^ "Albaconazole". Adis Insight. Springer Nature Switzerland AG.
^ Guedes PM, Urbina JA, de Lana M, Afonso LC, Veloso VM, Tafuri WL, et al. (November 2004). "Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts". Antimicrobial Agents and Chemotherapy. 48 (11): 4286–92. doi:10.1128/AAC.48.11.4286-4292.2004. PMC 525424. PMID 15504854.

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[1] "Albaconazole". Adis Insight. Springer Nature Switzerland AG.

[2] Guedes PM, Urbina JA, de Lana M, Afonso LC, Veloso VM, Tafuri WL, et al. (November 2004). "Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts". Antimicrobial Agents and Chemotherapy. 48 (11): 4286–92. doi:10.1128/AAC.48.11.4286-4292.2004. PMC 525424. PMID 15504854.

[1]

[2]

Clinical data

ATC code	none
Identifiers
IUPAC name 7-Chloro-3-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]quinazolin-4-one
CAS Number	187949-02-6^Y
PubChem CID	208952
ChemSpider	181045^Y
UNII	YDW24Y8IAB
KEGG	D09702^Y
ChEMBL	ChEMBL298817^Y
CompTox Dashboard (EPA)	DTXSID3058244
ECHA InfoCard	100.170.829
Chemical and physical data
Formula	C₂₀H₁₆ClF₂N₅O₂
Molar mass	431.83 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Fc1ccc(c(F)c1)[C@](O)([C@H](N3\C=N/c2cc(Cl)ccc2C3=O)C)Cn4ncnc4
InChI InChI=1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1^Y Key:UHIXWHUVLCAJQL-MPBGBICISA-N^Y
(verify)