All-trans-octaprenyl-diphosphate synthase

All-trans-octaprenyl-diphosphate synthase (EC 2.5.1.90, octaprenyl-diphosphate synthase, octaprenyl pyrophosphate synthetase, polyprenylpyrophosphate synthetase, terpenoidallyltransferase, terpenyl pyrophosphate synthetase, trans-heptaprenyltranstransferase, trans-prenyltransferase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 5 isopentenyl units).[1][2] This enzyme catalyses the following chemical reaction

All-trans-octaprenyl-diphosphate synthase
Identifiers
EC no.2.5.1.90
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins
(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate 5 diphosphate + all-trans-octaprenyl diphosphate

This enzyme catalyses the condensation reactions resulting in the formation of all-trans-octaprenyl diphosphate.

References

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  1. ^ Fujisaki S, Nishino T, Katsuki H (May 1986). "Isoprenoid synthesis in Escherichia coli. Separation and partial purification of four enzymes involved in the synthesis". Journal of Biochemistry. 99 (5): 1327–37. doi:10.1093/oxfordjournals.jbchem.a135600. PMID 3519603.
  2. ^ Asai K, Fujisaki S, Nishimura Y, Nishino T, Okada K, Nakagawa T, Kawamukai M, Matsuda H (July 1994). "The identification of Escherichia coli ispB (cel) gene encoding the octaprenyl diphosphate synthase". Biochemical and Biophysical Research Communications. 202 (1): 340–5. doi:10.1006/bbrc.1994.1933. PMID 8037730.
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