Alpha-gurjunene synthase

α-Gurjunene synthase (EC 4.2.3.72) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((–)-α-gurjunene-forming).[1] This enzyme catalyses the following chemical reaction

α-gurjunene synthase
Identifiers
EC no.4.2.3.72
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
(2E,6E)-farnesyl diphosphate (–)-α-gurjunene + diphosphate

Initial cyclization probably gives bicyclogermacrene in an enzyme-bound form.

References

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  1. ^ Schmidt CO, Bouwmeester HJ, Bülow N, König WA (April 1999). "Isolation, characterization, and mechanistic studies of (-)-α-gurjunene synthase from Solidago canadensis". Archives of Biochemistry and Biophysics. 364 (2): 167–77. doi:10.1006/abbi.1999.1122. PMID 10190971.
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