Alpha-seco-amyrin synthase

α-seco-amyrin synthase (EC 5.4.99.52) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, alpha-seco-amyrin-forming).[1] This enzyme catalyses the following chemical reaction

α-seco-amyrin synthase
Identifiers
EC no.5.4.99.52
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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(3S)-2,3-epoxy-2,3-dihydrosqualene alpha-seco-amyrin

The enzyme from Arabidopsis thaliana is multifunctional.

References

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  1. ^ Shibuya M, Xiang T, Katsube Y, Otsuka M, Zhang H, Ebizuka Y (February 2007). "Origin of structural diversity in natural triterpenes: direct synthesis of seco-triterpene skeletons by oxidosqualene cyclase". Journal of the American Chemical Society. 129 (5): 1450–5. doi:10.1021/ja066873w. PMID 17263431.
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