The alpha operon ribosome binding site in bacteria is surrounded by this complex pseudoknotted RNA structure. Translation of the mRNA produces 4 ribosomal protein products, one of which (S4) acts as a translational repressor by binding to the nested pseudoknot region. The mechanism of repression is thought to involve a conformational switch in the pseudoknot region and ribosome entrapment.[1]
| Alpha operon ribosome binding site | |
|---|---|
 Predicted secondary structure and sequence conservation of Alpha_RBS | |
| Identifiers | |
| Symbol | Alpha_RBS |
| Rfam | RF00140 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Bacteria |
| SO | SO:0000233 |
| PDB structures | PDBe |
References
edit- ^ Schlax PJ, Xavier KA, Gluick TC, Draper DE (October 2001). "Translational repression of the Escherichia coli alpha operon mRNA: importance of an mRNA conformational switch and a ternary entrapment complex". The Journal of Biological Chemistry. 276 (42): 38494–38501. doi:10.1074/jbc.M106934200. PMID 11504736.
External links
edit | This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. |