Altamirano is a Spanish surname. Notable people with the surname include:
- Armin Altamirano Luistro
- Carlos Altamirano (1922-2019), Chilean socialist politician
- Eric Altamirano(born 1966), Filipino basketball player and coach
- Fernando Altamirano (1848-1908), Mexican physician and botanist on
- Héctor Altamirano, Mexican footballer
- Ignacio Manuel Altamirano (1834-1893), Mexican novelist and politician
- Luis Altamirano
- Porfi Altamirano
- Pedro de Anda Altamirano