Amodei is a surname of Italian origin. It may refer to:
- Cataldo Amodei (1650–1695), Italian Baroque composer
- Fausto Amodei (born 1935), Italian singer-songwriter
- Ivan Amodei (born 1976), Italian magician
- Mark Amodei (born 1958), American politician
- Dario Amodei and Daniela Amodei, computer scientists, founders of Anthropic