Andrei N. Lupaș (born September 6, 1963, in Bucharest) is a German-Romanian biochemist, molecular biologist, and bioinformatician.[1]
Andrei Lupaș | |
|---|---|
| Born | September 6, 1963 |
| Education | Technical University of Munich Princeton University |
| Scientific career | |
| Institutions | Beecham Pharmaceuticals Max Planck Institute for Developmental Biology Max Planck Institute for Biology Max Planck Institute of Biochemistry |
| Doctoral advisor | Jeffry Stock |
| Other academic advisors | Andreas Plückthun Wolfgang Baumeister |
| Website | www |
Education and career
editLupaș was born in Bucharest, Romania, he began his studies in biology at the Technical University of Munich in 1982 before continuing his studies in molecular biology at Princeton University, where he received his PhD in 1991 with Jeffry Stock on the mechanism of signal transduction in bacterial chemotaxis. He then worked at the Max Planck Institute of Biochemistry in Martinsried in the Wolfgang Baumeister's department until 1997. From 1997 to 2001, he worked at SmithKline Beecham Pharmaceuticals in Collegeville. Since 2001, he has been the Director and Scientific Member at the Max Planck Institute for Developmental Biology (now Max Planck Institute for Biology).[1][2]
Research
editLupaș' research is largely on bioinformatics in combination with experimental structural biology. His earlier research focused on the prediction of coiled-coil structural elements[3] and of proteins, as well as calculations of structural homologies.[4] Other areas of focus for his research are the origins of early peptides and their evolution into modern domains and ultimately into proteins.[5]
In addition, his research group was involved in the development of the MPI Bioinformatics Toolkit.[6] His research has been funded by the German Research Foundation, the Volkswagen Foundation, the Wellcome Trust, and the Howard Hughes Medical Institute.
Lupaș was one of the judges at CASP14, where AlphaFold won.[7][8]
References
edit- ^ a b "Lupas, Andrei N." www.mpg.de. Retrieved 2022-12-14.
- ^ "The revolution in protein structure prediction". Naver Labs Europe. 2021-06-10. Retrieved 2022-12-14.
- ^ Lupas, Andrei; Van Dyke, Marc; Stock, Jeff (1991-05-24). "Predicting Coiled Coils from Protein Sequences". Science. 252 (5009): 1162–1164. Bibcode:1991Sci...252.1162L. doi:10.1126/science.252.5009.1162. ISSN 0036-8075. PMID 2031185. S2CID 2442386.
- ^ Soding, J.; Biegert, A.; Lupas, A. N. (2005-07-01). "The HHpred interactive server for protein homology detection and structure prediction". Nucleic Acids Research. 33 (Web Server): W244–W248. doi:10.1093/nar/gki408. ISSN 0305-1048. PMC 1160169. PMID 15980461.
- ^ "Andrei Lupas fascination for the complex world of proteins". www.gesundheitsindustrie-bw.de. Archived from the original on 2020-10-25. Retrieved 2022-12-14.
- ^ "Bioinformatics Toolkit". toolkit.tuebingen.mpg.de. Retrieved 2022-12-14.
- ^ "Home - CASP14". www.predictioncenter.org. Retrieved 2022-12-14.
- ^ Toews, Rob. "AlphaFold Is The Most Important Achievement In AI—Ever". Forbes. Retrieved 2022-12-14.