Andrej Šali (born 1963, Kranj, Slovenia) is a computational structural biologist. Since 2003, he has been Professor in the Department of Bioengineering and Therapeutic Sciences at University of California, San Francisco.[1] He also serves as an editor of the journal Structure.
Andrej Šali | |
|---|---|
 Šali speaking at ISMB 2012. | |
| Born | 1963 (age 60–61) |
| Alma mater | Birkbeck College, University of London |
| Scientific career | |
| Institutions | University of California, San Francisco Harvard University Rockefeller University Birkbeck College, University of London University of Ljubljana |
| Thesis | Modelling three-dimensional structure of a protein from its amino acid sequence (1991) |
| Doctoral advisor | Tom Blundell |
| Website | www |
Education
editŠali received his Bachelor of Science degree in chemistry from University of Ljubljana, 1987; his Ph.D. in Molecular Biophysics from Birkbeck College,[2] University of London, 1991 (working with Tom Blundell); and did postdoctoral work at Harvard University (working with Martin Karplus).
Research
editSali joined the faculty of the Rockefeller University in 1995, following his postdoctoral research at Harvard University. He is using computation grounded in the laws of physics and evolution to study the structure and function of proteins. For example, he developed comparative protein structure modeling by satisfaction of spatial restraints, implemented in program MODELLER[3] and integrative structure determination of macromolecular assemblies, implemented in program IMP.[4]
Research impact
editSali contributes greatly to structural biology by developing and applying computational methods for structural modeling and analysis of proteins. The two most often used programs developed by his research group include "MODELLER" for comparative protein structure modeling and "IMP" for integrative structure determination.
As of January 2022, Šali published approximately 400 papers,[5] which were cited approximately 89,000 times per Google Scholar. His Hirsch-index is 132 (i.e., 132 publication have been cited at least 132 times).
In 2018, Šali was elected member of the National Academy of Sciences in recognition of his contributions to biophysics and computational biology.[6]
Notable alumni from Šali Lab
edit| Name | Lab Position | Duration | Current Location | Current Position |
|---|---|---|---|---|
| Frank Alber | Postdoctoral Fellow | University of California, Los Angeles, California, USA | Professor | |
| Andras Fiser | Postdoctoral Fellow | Sep 1997 to Dec 2002 | Albert Einstein College of Medicine, Bronx, NY | Professor |
| Rachel Karchin | Postdoctoral Fellow | Aug 2003 to Aug 2006 | Johns Hopkins University | Associate Professor |
| Dmitry Korkin | Postdoctoral Fellow | Sep 2002 to Jul 2007 | Worcester Polytechnic Institute | Professor |
| Marc A. Marti-Renom | Postdoctoral Fellow
Adjunct Assistant Professor |
Feb 1999 to Jun 2006 | National Center for Genomic Analysis (CNAG), Barcelona, Spain | Group Leader |
| M.S. Madhusudhan | Postdoctoral Fellow | Feb 2000 to Mar 2008 | IISER, Pune, India | Associate Professor |
| Maya Topf | Postdoctoral Fellow | 2003 to 2006 | Centre for Structural Systems Biology, Hamburg, Germany | Professor |
| David Barkan | Ph.D. Student | Sept 2006 to Oct 2011 | Protagonist Therapeutics | Staff Scientist |
References
edit- ^ Andrej Šali publications indexed by Microsoft Academic
- ^ Sali, Andrej (1984). Modelling three-dimensional structure of a protein from its amino acid sequence (PhD thesis). London, Birkbeck College.
- ^ Šali, A.; Blundell, T. L. (1993). "Comparative Protein Modelling by Satisfaction of Spatial Restraints". Journal of Molecular Biology. 234 (3): 779–815. doi:10.1006/jmbi.1993.1626. PMID 8254673.
- ^ Russel, D.; Lasker, K.; Webb, B.; Velázquez-Muriel, J.; Tjioe, E.; Schneidman-Duhovny, D.; Peterson, B.; Sali, A. (2012). "Putting the Pieces Together: Integrative Modeling Platform Software for Structure Determination of Macromolecular Assemblies". PLOS Biology. 10 (1): e1001244. doi:10.1371/journal.pbio.1001244. PMC 3260315. PMID 22272186.
- ^ Andrej Šali’s Publications
- ^ "Andrej Sali". National Academy of Sciences. Retrieved 2018-07-23.