Anfossi is a surname. Notable people with the surname include:
- Filippo Anfossi (died 1825), Vicar-General of the Dominican Order
- Giuseppe Anfossi (born 1935), Roman Catholic bishop
- Pasquale Anfossi (1727–1797), Italian opera composer
- Vincenzo da Via Anfossi (born 1972), Italian rapper
- James Anfossi (born 1992), QBE Underwriter