Angelika Gründling (born 1972) is an Austrian microbiologist who is Professor of Molecular Microbiology at Imperial College London. Her research considers Staphylococcus aureus, nucleotide signalling and cell wall biosynthesis. She was elected a Fellow of the European Academy of Microbiology in 2018.
Angelika Gründling | |
|---|---|
| Born | 1972 (age 51–52) |
| Alma mater | University of Vienna |
| Scientific career | |
| Institutions | Imperial College London University of Chicago Harvard Medical School |
Early life and education
editGründling completed her undergraduate studies at the University of Vienna.[1] She conducted doctoral research with Ry Young at Texas A&M University.[citation needed] She moved to Harvard Medical School, where she studied the mobility of Listeria monocytogenes supported by an Erwin Schrödinger postdoctoral fellowship. There she investigated the motility of the flagellum in bacterial pathogen Listeria monocytogenes. Gründling moved to the Schneewind laboratory at the University of Chicago, where she investigated the cell wall of Staphylococcus aureus.[2] As a postdoctoral researcher, she discovered the enzyme needed to make lipoteichoic acid, lipoteichoic acid synthase.[3]
Research and career
editIn 2007, Gründling joined Imperial College London, where she was promoted to Professor in 2015.[citation needed] Her group study the mechanisms that underpin the growth of Gram-positive bacterial pathogens. She studies the synthesis of cell walls and various pathways for nucleotide signalling in Staphylococcus aureus and Listeria monocytogenes.
She studied membrane function at Harvard Medical School.[4] In particular, Gründling was interested in the mechanisms that underpin the growth of the bacterial membrane.[4] Bacteria are composted of a phospholipid bilayer, mainly composed of phosphatidylglycerol, the enzymes of which have barely been characterised. She used genetic methods to unravel the mechanisms behind lipid transfer within the membrane and to identify the proteins required for membrane construction.[4]
Awards and honours
edit- 2009 Interscience Conference on Antimicrobial Agents and Chemotherapy Young Investigator Award[3]
- 2010 Fellow of the Higher Education Academy[5]
- 2014 Fellow of the Royal Society of Biology[5]
- 2018 Fellow of the European Academy of Microbiology[6]
Selected publications
edit- Rebecca M Corrigan; James C Abbott; Heike Burhenne; Volkhard Kaever; Angelika Gründling (1 September 2011). "c-di-AMP is a new second messenger in Staphylococcus aureus with a role in controlling cell size and envelope stress". PLOS Pathogens. 7 (9): e1002217. doi:10.1371/JOURNAL.PPAT.1002217. ISSN 1553-7366. PMC 3164647. PMID 21909268. Wikidata Q34016233.
- Matthew G Percy; Angelika Gründling (5 May 2014). "Lipoteichoic acid synthesis and function in gram-positive bacteria". Annual Review of Microbiology. 68: 81–100. doi:10.1146/ANNUREV-MICRO-091213-112949. ISSN 0066-4227. PMID 24819367. Wikidata Q38211157.
- Rebecca M Corrigan; Angelika Gründling (1 July 2013). "Cyclic di-AMP: another second messenger enters the fray". Nature Reviews Microbiology. 11 (8): 513–524. doi:10.1038/NRMICRO3069. ISSN 1740-1534. PMID 23812326. Wikidata Q38118107.
References
edit- ^ Gründling, Angelika; Manson, Michael D.; Young, Ry (2001-07-31). "Holins kill without warning". Proceedings of the National Academy of Sciences. 98 (16): 9348–9352. doi:10.1073/pnas.151247598. ISSN 0027-8424. PMC 55423. PMID 11459934.
- ^ "FEMS Expert: Prof Angelika Gründling". FEMS. Retrieved 2024-03-03.
- ^ a b "Understanding the Building Blocks of Bacteria". 2012-09-12.
- ^ a b c "Angelika Grundling". Bernhardt lab. Retrieved 2024-03-03.
- ^ a b "Honours and Memberships - Professor Angelika Gründling". www.imperial.ac.uk. Retrieved 2024-03-03.
- ^ "Fellows". FEMS. Retrieved 2024-03-03.