Angiomotin-like protein 1

Angiomotin-like protein 1 is a protein that in humans is encoded by the AMOTL1 gene.

AMOTL1
Identifiers
Aliases	AMOTL1, JEAP, angiomotin like 1
External IDs	OMIM: 614657; MGI: 1922973; HomoloGene: 43977; GeneCards: AMOTL1; OMA:AMOTL1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q21 Start 94,706,431 bp End 94,876,748 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A2 Start 14,453,262 bp End 14,556,352 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle deltoid muscle Skeletal muscle tissue of rectus abdominis cardiac muscle tissue of right atrium tendon of biceps brachii body of tongue tibia quadriceps femoris muscle skin of arm vastus lateralis muscle Top expressed in hand knee joint foot soleus muscle temporal muscle lateral geniculate nucleus medial head of gastrocnemius muscle triceps brachii muscle sternocleidomastoid muscle quadriceps femoris muscle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding identical protein binding Cellular component COP9 signalosome cytosol apical plasma membrane cytoplasmic vesicle lamellipodium bicellular tight junction cell junction Biological process establishment of cell polarity involved in ameboidal cell migration Wnt signaling pathway hippo signaling positive regulation of blood vessel endothelial cell migration actin cytoskeleton organization regulation of cell migration angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 154810 75723 Ensembl ENSG00000166025 ENSMUSG00000013076 UniProt Q8IY63 Q9D4H4 RefSeq (mRNA) NM_001301007 NM_130847 NM_001081395 RefSeq (protein) NP_001287936 NP_570899 NP_570899.1 NP_001074864 Location (UCSC) Chr 11: 94.71 – 94.88 Mb Chr 9: 14.45 – 14.56 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.

External links

• Human AMOTL1 genome location and AMOTL1 gene details page in the UCSC Genome Browser.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Bratt A, Wilson WJ, Troyanovsky B, et al. (2003). "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains". Gene. 298 (1): 69–77. doi:10.1016/S0378-1119(02)00928-9. PMID 12406577.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Patrie KM (2005). "Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1". Biochim. Biophys. Acta. 1745 (1): 131–44. doi:10.1016/j.bbamcr.2005.05.011. PMID 16019084.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.