Annexin A13

Annexin A13 is a protein that in humans is encoded by the ANXA13 gene.

ANXA13
Identifiers
Aliases	ANXA13, ANX13, ISA, annexin A13
External IDs	OMIM: 602573; MGI: 1917037; HomoloGene: 20908; GeneCards: ANXA13; OMA:ANXA13 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q24.13 Start 123,680,794 bp End 123,737,402 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 D1|15 24.66 cM Start 58,204,867 bp End 58,261,093 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder jejunal mucosa duodenum right uterine tube rectum pancreatic ductal cell mucosa of transverse colon mucosa of sigmoid colon C1 segment mucosa of ileum Top expressed in duodenum jejunum ileum pancreas colon islet of Langerhans stomach connecting tubule midgut proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium-dependent phospholipid binding calcium ion binding phosphatidylserine binding phosphatidylcholine binding phosphatidylglycerol binding Cellular component membrane raft plasma membrane basolateral plasma membrane extracellular exosome apical plasma membrane exocytic vesicle membrane nucleoplasm extracellular space Biological process positive regulation of Golgi to plasma membrane protein transport cell differentiation negative regulation of Golgi to plasma membrane protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 312 69787 Ensembl ENSG00000104537 ENSMUSG00000055114 UniProt P27216 Q99JG3 RefSeq (mRNA) NM_004306 NM_001003954 NM_027211 RefSeq (protein) NP_001003954 NP_004297 NP_081487 Location (UCSC) Chr 8: 123.68 – 123.74 Mb Chr 15: 58.2 – 58.26 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membranes of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified.

External links

• Human ANXA13 genome location and ANXA13 gene details page in the UCSC Genome Browser.

Further reading

• Wice BM, Gordon JI (Jan 1992). "A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin". The Journal of Cell Biology. 116 (2): 405–22. doi:10.1083/jcb.116.2.405. PMC 2289284. PMID 1530946.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Plant PJ, Lafont F, Lecat S, Verkade P, Simons K, Rotin D (Jun 2000). "Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb". The Journal of Cell Biology. 149 (7): 1473–84. doi:10.1083/jcb.149.7.1473. PMC 2175132. PMID 10871286.
• Noda Y, Okada Y, Saito N, Setou M, Xu Y, Zhang Z, Hirokawa N (Oct 2001). "KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes". The Journal of Cell Biology. 155 (1): 77–88. doi:10.1083/jcb.200108042. PMC 2150803. PMID 11581287.
• Iglesias JM, Morgan RO, Jenkins NA, Copeland NG, Gilbert DJ, Fernandez MP (May 2002). "Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins". Molecular Biology and Evolution. 19 (5): 608–18. doi:10.1093/oxfordjournals.molbev.a004120. PMID 11961095.
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.