The anterior olfactory nucleus (AON; also called the anterior olfactory cortex) is a portion of the forebrain of vertebrates.
| Anterior olfactory nucleus | |
|---|---|
 Human brainstem anterior view (Anterior olfactory nucleus is not labeled, but region is visible at center top, approximately between the "2" and the "3".) | |
| Details | |
| Identifiers | |
| Latin | nucleus olfactorius anterior |
| NeuroNames | 280 |
| NeuroLex ID | birnlex_1085 |
| TA98 | A14.1.09.416 |
| TA2 | 5543 |
| FMA | 77628 |
| Anatomical terms of neuroanatomy | |
It is involved in olfaction[1] and has supposedly strong influence on other olfactory areas like the olfactory bulb and the piriform cortex.[2]
Structure
editThe AON is found behind the olfactory bulb and in front of the piriform cortex (laterally) and olfactory tubercle (medially) in a region known as the olfactory peduncle[3] or retrobulbar area. The peduncle contains the AON as well as two other much smaller regions, the taenia tecta (or dorsal hippocampal rudiment) and the dorsal peduncular cortex.
Function
editThe AON plays a pivotal but relatively poorly understood role in the processing of odor information.
Odors enter the nose (or olfactory rosette in fishes) and interact with the cilia of olfactory receptor neurons. The information is sent via the olfactory nerve (Cranial Nerve I) to the olfactory bulb. After the processing in the bulb the signal is transmitted caudally via the axons of mitral and tufted cells in the lateral olfactory tract. The tract forms on the ventrolateral surface of the brain and passes through the AON, continuing on to run the length of the piriform cortex, while synapsing in both regions. The AON distributes the information to the contralateral olfactory bulb and piriform cortex as well as engaging in reciprocal interactions with the ipsilateral bulb and cortex. Therefore, the AON is positioned to regulate information flow between nearly every region where odor information processing occurs.
Components
editThe AON is composed of two separate structures:
- a) a thin ring of cells encircling the rostral end of the olfactory peduncle known as “pars externa”,
- b) the large “pars principalis”, seen in coronal sections of most mammalian brains as a two-layered structure.
- The deepest (Layer II) is a thick ring of pyramidal and other-shaped cells surrounding the anterior limb of the anterior commissure.
- The outer, cell-poor layer, is often subdivided into a superficial zone (Layer Ia, which contains the output axons from the olfactory bulb) and a deeper area (Layer Ib).
- Many divide pars principalis on the basis of the ‘compass points,’ yielding pars dorsalis, pars ventralis, pars medialis, pars lateralis, and pars posterioralis (often combined with pars ventralis to form “pars ventroposterioralis”).
References
edit- ^ Saiz-Sanchez D, Ubeda-Bañon I, de la Rosa-Prieto C, et al. (June 2009). "Somatostatin, tau, and beta-amyloid within the anterior olfactory nucleus in Alzheimer disease". Exp. Neurol. 223 (2): 347–350. doi:10.1016/j.expneurol.2009.06.010. PMID 19559700.
- ^ Peter C. Brunjes; Kurt R. Illig; Elizabeth A. Meyer (2005). "A field guide to the anterior olfactory nucleus (cortex)". Brain Research Reviews. 50 (2): 305–335. doi:10.1016/j.brainresrev.2005.08.005.
- ^ "BrainInfo". braininfo.rprc.washington.edu. Retrieved 15 November 2021.
- Brunjes, PC; Illig, KR; Meyer, EA (December 2005). "A field guide to the anterior olfactory nucleus/cortex". Brain Research Reviews. 50 (2): 305–335. doi:10.1016/j.brainresrev.2005.08.005. PMID 16229895.
External links
edit- "1-4". Cranial Nerves. Yale School of Medicine. Archived from the original on 2016-03-03.
- NIF Search - Anterior Olfactory Nucleus via the Neuroscience Information Framework