Antonio G. Siccardi (born 1 October 1944, Varese) is an Italian immunologist and virologist.
Antonio Siccardi | |
|---|---|
| Born | October 1, 1944 |
| Nationality | Italian |
| Academic background | |
| Alma mater | University of Pavia |
| Academic work | |
| Discipline | Immunology Virology |
| Institutions | University of Milan |
Siccardi studied at the medical faculty of the University of Pavia and received his M.D. in 1968.[1] He later became associate professor for genetics (1973 to 1980) and then for microbiology (1974 to 1980).[2] After a short research trip to Rome as a full professor (1980 to 1982), he became full Professor for molecular immunology at the University of Milan from 1982 until today.[2] From 1990 to 1994 he was Operative Director of the DIBIT, San Raffaele Scientific Institute in Milan.[2] From 1991 to 1998 he coordinated the HIV/AIDS research at the Ospedale San Raffaele of the University of Milan.[2] He is (2015) professor for molecular immunology at the university of Milan and member of the board of the Istituto Nazionale di Genetica Molecolare (INGM).[3] From 2000 to 2008 he also was a deputy professor for genetics at the Faculty of Psychology of the Università Vita-Salute San Raffaele in Milan and from 2006 to today (2015) deputy professor for History of Molecular Genetics at the Faculty of Biotechnology of the Università Vita Salute San Raffaele.[2]
Siccardi's areas of research comprise HIV,[4][5][6] influenza,[7] cancer (especially mesothelioma),[8][9] immunoglobulin E,[10] and vaccine design of recombinant Modified Vaccinia Ankara virus (MVA) or Fowlpoxvirus.[7] Siccardi developed a recombinant MVA-based vector for vaccination with different fluorescent reporter genes, which indicate the progress of genetic recombination with the transgene of an antigen (green, colorless, red).[7][11]
References
edit- ^ biography of Antonio Siccardi Archived 2015-02-17 at the Wayback Machine at the AllergoOncology Symposium 2008.
- ^ a b c d e CV of Antonio Siccardi Archived 2015-02-17 at the Wayback Machine. University of Milan.
- ^ Jannis Kounellis per il charity project "all'Arte" (Italian). Men's Vogue Italy, May 22, 2014.
- ^ Was zur Hölle sind Chemokine? (German). Interview with Robert Gallo, Der Spiegel no. 50, 1995.
- ^ Grassi, F; Meneveri, R; Gullberg, M; Lopalco, L; Rossi, G. B.; Lanza, P; De Santis, C; Brattsand, G; Buttò, S; Ginelli, E (1991). "Human immunodeficiency virus type 1 gp120 mimics a hidden monomorphic epitope borne by class I major histocompatibility complex heavy chains". The Journal of Experimental Medicine. 174 (1): 53–62. doi:10.1084/jem.174.1.53. PMC 2118897. PMID 1711567.
- ^ Scarlatti, G; Tresoldi, E; Björndal, A; Fredriksson, R; Colognesi, C; Deng, H. K.; Malnati, M. S.; Plebani, A; Siccardi, A. G.; Littman, D. R.; Fenyö, E. M.; Lusso, P (1997). "In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression". Nature Medicine. 3 (11): 1259–65. doi:10.1038/nm1197-1259. PMID 9359702. S2CID 28713999.
- ^ a b c Soprana, E; Panigada, M; Knauf, M; Radaelli, A; Vigevani, L; Palini, A; Villa, C; Malnati, M; Cassina, G; Kurth, R; Norley, S; Siccardi, A. G. (2011). "Joint production of prime/boost pairs of Fowlpox Virus and Modified Vaccinia Ankara recombinants carrying the same transgene". Journal of Virological Methods. 174 (1–2): 22–8. doi:10.1016/j.jviromet.2011.03.013. PMID 21419167.
- ^ Guttinger, M; Guidi, F; Chinol, M; Reali, E; Veglia, F; Viale, G; Paganelli, G; Corti, A; Siccardi, A. G. (2000). "Adoptive immunotherapy by avidin-driven cytotoxic T lymphocyte-tumor bridging". Cancer Research. 60 (15): 4211–5. PMID 10945632.
- ^ Nigro, E. A.; Brini, A. T.; Soprana, E; Ambrosi, A; Dombrowicz, D; Siccardi, A. G.; Vangelista, L (2009). "Antitumor IgE adjuvanticity: Key role of Fc epsilon RI". The Journal of Immunology. 183 (7): 4530–6. doi:10.4049/jimmunol.0900842. hdl:2434/71709. PMID 19748979.
- ^ Vangelista, L; Soprana, E; Cesco-Gaspere, M; Mandiola, P; Di Lullo, G; Fucci, R. N.; Codazzi, F; Palini, A; Paganelli, G; Burrone, O. R.; Siccardi, A. G. (2005). "Membrane IgE binds and activates Fc epsilon RI in an antigen-independent manner". Journal of Immunology. 174 (9): 5602–11. doi:10.4049/jimmunol.174.9.5602. PMID 15843559.
- ^ Di Lullo, G; Soprana, E; Panigada, M; Palini, A; Erfle, V; Staib, C; Sutter, G; Siccardi, A. G. (2009). "Marker gene swapping facilitates recombinant Modified Vaccinia Virus Ankara production by host-range selection". Journal of Virological Methods. 156 (1–2): 37–43. doi:10.1016/j.jviromet.2008.10.026. PMID 19038289.