Apalachicola people may refer to:
- Apalachicola band, an association of towns on the Apalachicola River in Florida in the early 19th century
- Apalachicola Province, an association of towns on the Chattahoochee River in Alabama and Georgia (USA) that became the Lower Towns of the Muscogee Confederacy
- Apalachicola (tribal town), the namesake town of the Apalachicola Province
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