Appalachia is a socioeconomic region associated with the Appalachian Mountains in the eastern United States.
Appalachia may also refer to:
- Appalachian (disambiguation)
- Appalachia (Mesozoic), a Mesozoic-era island
- Appalachia, Virginia, a town in the U.S. state of Virginia
- Appalachia, a rhapsody by Frederick Delius
- Appalachia (journal), a mountaineering and conservation journal published by the Appalachian Mountain Club since 1894
- Appalachia (grasshopper), a genus of grasshoppers in the Acrididae family