Aquaporin-7

Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene.

AQP7
Identifiers
Aliases	AQP7, AQP7L, AQP9, AQPap, GLYCQTL, aquaporin 7
External IDs	OMIM: 602974; MGI: 1314647; HomoloGene: 48000; GeneCards: AQP7; OMA:AQP7 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p13.3 Start 33,383,179 bp End 33,402,682 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A5 Start 41,033,074 bp End 41,048,139 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart subcutaneous adipose tissue left ventricle sural nerve right auricle muscle of thigh lactiferous gland gastric mucosa duodenum quadriceps femoris muscle Top expressed in spermatid seminiferous tubule brown adipose tissue aortic valve white adipose tissue proximal tubule right kidney tunica adventitia of aorta ascending aorta muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycerol channel activity water channel activity channel activity urea transmembrane transporter activity Cellular component cytoplasm integral component of membrane plasma membrane integral component of plasma membrane membrane cell-cell junction lipid droplet cell cortex cytoplasmic vesicle membrane cytoplasmic vesicle Biological process water transport excretion glycerol transport generation of precursor metabolites and energy transmembrane transport urea transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 364 11832 Ensembl ENSG00000165269 ENSMUSG00000028427 UniProt O14520 O54794 RefSeq (mRNA) NM_001170 NM_001318156 NM_001318157 NM_001318158 NM_001376191 NM_001376192 NM_001376193 NM_007473 RefSeq (protein) NP_001161 NP_001305085 NP_001305086 NP_001305087 NP_001363120 NP_001363121 NP_001363122 NP_031499 NP_001365567 NP_001365568 NP_001365569 NP_001365570 NP_001365571 Location (UCSC) Chr 9: 33.38 – 33.4 Mb Chr 4: 41.03 – 41.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Aquaporins/major intrinsic proteins (MIP) are a family of water-selective membrane channels. Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin-7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin-7 facilitates water, glycerol and urea transport. It may play an important role in thermoregulation in the form of perspiration, and sperm function.

Further reading

• Dibas AI, Mia AJ, Yorio T (1998). "Aquaporins (water channels): role in vasopressin-activated water transport". Proc. Soc. Exp. Biol. Med. 219 (3): 183–99. doi:10.3181/00379727-219-44332. PMID 9824541. S2CID 28952956.
• Kuriyama H, Kawamoto S, Ishida N, et al. (1998). "Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability". Biochem. Biophys. Res. Commun. 241 (1): 53–8. doi:10.1006/bbrc.1997.7769. PMID 9405233.
• Ishibashi K, Yamauchi K, Kageyama Y, et al. (1998). "Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping". Biochim. Biophys. Acta. 1399 (1): 62–6. doi:10.1016/s0167-4781(98)00094-3. PMID 9714739.
• Suzuki-Toyota F, Ishibashi K, Yuasa S (1999). "Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis". Cell Tissue Res. 295 (2): 279–85. doi:10.1007/s004410051234. PMID 9931374. S2CID 30916397.
• Kondo H, Shimomura I, Kishida K, et al. (2002). "Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation". Eur. J. Biochem. 269 (7): 1814–26. doi:10.1046/j.1432-1033.2002.02821.x. PMID 11952783.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLOS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
• Marrades MP, Milagro FI, Martínez JA, Moreno-Aliaga MJ (2006). "Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers". Biochem. Biophys. Res. Commun. 339 (3): 785–9. doi:10.1016/j.bbrc.2005.11.080. PMID 16325777.
• Prudente S, Flex E, Morini E, et al. (2007). "A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities". Diabetes. 56 (5): 1468–74. doi:10.2337/db06-1389. PMID 17351148.
• Ceperuelo-Mallafré V, Miranda M, Chacón MR, et al. (2007). "Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes". J. Clin. Endocrinol. Metab. 92 (9): 3640–5. doi:10.1210/jc.2007-0531. PMID 17566090.

External links

• AQP7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human AQP7 genome location and AQP7 gene details page in the UCSC Genome Browser.
• Human AQP9 genome location and AQP9 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.