An arabinosyltransferase is a transferase enzyme acting upon arabinose.[1] This enzyme is involved in polymerisation of arabinogalactan (an essential component of the mycobacterial cell wall). Mycobacterially, the more precise term is arabinofuranosyltransferase, since the arabinose residues occur only in a furanose form.
| Arabinosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Arabinose_trans | ||||||||
| Pfam | PF04602 | ||||||||
| Pfam clan | CL0111 | ||||||||
| InterPro | IPR007680 | ||||||||
| CAZy | GT53 | ||||||||
| |||||||||
This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug ethambutol.[2]
References
edit- ^ Zhang J, Angala SK, Pramanik PK, Li K, Crick DC, Liav A, Jozwiak A, Swiezewska E, Jackson M, Chatterjee D (2011). "Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donors". ACS Chem. Biol. 6 (8): 819–28. doi:10.1021/cb200091m. PMC 3158817. PMID 21595486.
- ^ Belanger AE, Besra GS, Ford ME, Mikusova K, Belisle JT, Brennan PJ, Inamine JM (October 1996). "The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11919–24. Bibcode:1996PNAS...9311919B. doi:10.1073/pnas.93.21.11919. PMC 38159. PMID 8876238.