Arquette is a surname; people with this name include the following members of the Arquette family:
- Alexis Arquette, American transgender actress
- Cliff Arquette, American actor, father of Lewis Arquette
- David Arquette, American actor and a former WCW World Heavyweight Champion, and ex-husband of American actress Courteney Cox
- Lewis Arquette, American actor, father of Alexis, David, Patricia, Richmond and Rosanna
- Patricia Arquette, American actress
- Rosanna Arquette, American actress