Asc-type amino acid transporter 1

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Asc-type amino acid transporter 1 (Asc-1) is a protein that in humans is encoded by the SLC7A10 gene.^[5]^[6]^[7]

SLC7A10

Identifiers

SLC7A10, HASC-1, asc-1, ASC1, solute carrier family 7 member 10

External IDs

OMIM: 607959; MGI: 1858261; HomoloGene: 56767; GeneCards: SLC7A10; OMA:SLC7A10 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.11	Start	33,208,664 bp^[1]
Band	19q13.11	End	33,225,850 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7 B2\|7 21.13 cM	Start	34,885,810 bp^[2]
Band	7 B2\|7 21.13 cM	End	34,900,539 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

caudate nucleus

nucleus accumbens

putamen

amygdala

subcutaneous adipose tissue

right frontal lobe

anterior cingulate cortex

gonad

hypothalamus

substantia nigra

Top expressed in

lumbar subsegment of spinal cord

deep cerebellar nuclei

medial vestibular nucleus

white adipose tissue

Epithelium of choroid plexus

central gray substance of midbrain

mammillary body

dorsal tegmental nucleus

subcutaneous adipose tissue

inferior colliculi

More reference expression data

n/a

Gene ontology
Molecular function	antiporter activity L-serine transmembrane transporter activity neutral amino acid transmembrane transporter activity transmembrane transporter activity L-amino acid transmembrane transporter activity
Cellular component	integral component of membrane plasma membrane membrane integral component of plasma membrane
Biological process	leukocyte migration neutral amino acid transport D-alanine transport amino acid transport D-serine transport L-serine transport transmembrane transport L-alpha-amino acid transmembrane transport
Sources:Amigo / QuickGO

Species

Human

Mouse


56301


53896


ENSG00000130876


ENSMUSG00000030495


Q9NS82


P63115

RefSeq (mRNA)


NM_019849


NM_017394

RefSeq (protein)


NP_062823


NP_059090

Location (UCSC)

Chr 19: 33.21 – 33.23 Mb

Chr 7: 34.89 – 34.9 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

See also

Heterodimeric amino acid transporter

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130876 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030495 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 10".
^ Fukasawa Y, Segawa H, Kim JY, Chairoungdua A, Kim DK, Matsuo H, Cha SH, Endou H, Kanai Y (March 2000). "Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids". J. Biol. Chem. 275 (13): 9690–8. doi:10.1074/jbc.275.13.9690. PMID 10734121.
^ Nakauchi J, Matsuo H, Kim DK, Goto A, Chairoungdua A, Cha SH, Inatomi J, Shiokawa Y, Yamaguchi K, Saito I, Endou H, Kanai Y (June 2000). "Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity". Neurosci. Lett. 287 (3): 231–5. doi:10.1016/S0304-3940(00)01169-1. PMID 10863037. S2CID 23904731.

Further reading

Leclerc D, Wu Q, Ellis JR, et al. (2001). "Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria?". Mol. Genet. Metab. 73 (4): 333–9. doi:10.1006/mgme.2001.3209. PMID 11509015.
Imielinski M, Baldassano RN, Griffiths A, et al. (2009). "Common variants at five new loci associated with early-onset inflammatory bowel disease". Nat. Genet. 41 (12): 1335–40. doi:10.1038/ng.489. PMC 3267927. PMID 19915574.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Pineda M, Font M, Bassi MT, et al. (2004). "The amino acid transporter asc-1 is not involved in cystinuria". Kidney Int. 66 (4): 1453–64. doi:10.1111/j.1523-1755.2004.00908.x. PMID 15458438.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184. S2CID 826987.
Bröer S (January 2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
Xu D, Hemler ME (2005). "Metabolic activation-related CD147-CD98 complex". Mol. Cell. Proteomics. 4 (8): 1061–71. doi:10.1074/mcp.M400207-MCP200. PMC 1351277. PMID 15901826.

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