Asialoglycoprotein receptor 1

Asialoglycoprotein receptor 1 is a protein that in humans is encoded by the ASGR1 gene.

ASGR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DV8
Identifiers
Aliases	ASGR1, ASGPR, ASGPR1, CLEC4H1, HL-1, asialoglycoprotein receptor 1
External IDs	OMIM: 108360; MGI: 88081; HomoloGene: 1263; GeneCards: ASGR1; OMA:ASGR1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.1 Start 7,173,431 bp End 7,179,564 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B3|11 42.98 cM Start 69,944,911 bp End 69,948,720 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver monocyte granulocyte left testis cerebellar hemisphere right hemisphere of cerebellum right testis ganglionic eminence right frontal lobe blood Top expressed in left lobe of liver gallbladder embryo lacrimal gland parotid gland embryo optic nerve dentate gyrus of hippocampal formation granule cell trachea cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding carbohydrate binding protein homodimerization activity asialoglycoprotein receptor activity Cellular component integral component of membrane extracellular region integral component of plasma membrane membrane plasma membrane Biological process endocytosis receptor-mediated endocytosis cellular response to extracellular stimulus protein N-linked glycosylation via asparagine viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 432 11889 Ensembl ENSG00000141505 ENSMUSG00000020884 UniProt P07306 P34927 RefSeq (mRNA) NM_001197216 NM_001671 NM_001291131 NM_001291132 NM_009714 RefSeq (protein) NP_001184145 NP_001662 NP_001278060 NP_001278061 NP_033844 Location (UCSC) Chr 17: 7.17 – 7.18 Mb Chr 11: 69.94 – 69.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Further reading

• Yik JH, Saxena A, Weigel PH (June 2002). "The minor subunit splice variants, H2b and H2c, of the human asialoglycoprotein receptor are present with the major subunit H1 in different hetero-oligomeric receptor complexes". J. Biol. Chem. 277 (25): 23076–83. doi:10.1074/jbc.M202748200. PMID 11943787.
• Seow YY, Tan MG, Woo KT (July 2002). "Expression of a functional asialoglycoprotein receptor in human renal proximal tubular epithelial cells". Nephron. 91 (3): 431–8. doi:10.1159/000064283. PMID 12119473. S2CID 46876654.
• Huang T, Deng H, Wolkoff AW, Stockert RJ (October 2002). "Phosphorylation-dependent interaction of the asialoglycoprotein receptor with molecular chaperones". J. Biol. Chem. 277 (40): 37798–803. doi:10.1074/jbc.M204786200. PMID 12167617.
• Yik JH, Saxena A, Weigel JA, Weigel PH (October 2002). "Palmitoylation-defective asialoglycoprotein receptors are normal in their cellular distribution and ability to bind ligand, but are defective in ligand uptake and degradation". Biochem. Biophys. Res. Commun. 297 (4): 980–6. doi:10.1016/s0006-291x(02)02298-2. PMID 12359251.
• Yik JH, Weigel PH (December 2002). "The position of cysteine relative to the transmembrane domain is critical for palmitoylation of H1, the major subunit of the human asialoglycoprotein receptor". J. Biol. Chem. 277 (49): 47305–12. doi:10.1074/jbc.M208751200. PMID 12370180.
• Sørensen AL, Rumjantseva V, Nayeb-Hashemi S, Clausen H, Hartwig JH, Wandall HH, Hoffmeister KM (August 2009). "Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes". Blood. 114 (8): 1645–54. doi:10.1182/blood-2009-01-199414. PMC 2731641. PMID 19520807.
• Yang J, Wang F, Tian L, Su J, Zhu X, Lin L, Ding X, Wang X, Wang S (June 2010). "Fibronectin and asialoglyprotein receptor mediate hepatitis B surface antigen binding to the cell surface". Arch. Virol. 155 (6): 881–8. doi:10.1007/s00705-010-0657-5. PMID 20364278. S2CID 20899009.
• Liu J, Hu B, Yang Y, Ma Z, Yu Y, Liu S, Wang B, Zhao X, Lu M, Yang D (September 2010). "A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes". PLOS ONE. 5 (9): e12934. Bibcode:2010PLoSO...512934L. doi:10.1371/journal.pone.0012934. PMC 2944864. PMID 20886072.
• Zhang X, Lin SM, Chen TY, Liu M, Ye F, Chen YR, Shi L, He YL, Wu LX, Zheng SQ, Zhao YR, Zhang SL (April 2011). "Asialoglycoprotein receptor interacts with the preS1 domain of hepatitis B virus in vivo and in vitro". Arch. Virol. 156 (4): 637–45. doi:10.1007/s00705-010-0903-x. PMID 21207081. S2CID 20356590.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.