Asoprisnil

Asoprisnil
Clinical data
ATC code	None;
Identifiers
	IUPAC name (8S,11R,13S,14S,17S)-11-[4-[(E)-hydroxyiminomethyl]phenyl]-17-methoxy-17-(methoxymethyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one;
CAS Number	199396-76-4 ;
PubChem CID	9577221;
IUPHAR/BPS	2883;
ChemSpider	7851660 ;
UNII	72W09924WP;
KEGG	D02996 ;
ChEMBL	ChEMBL267431 ;
CompTox Dashboard (EPA)	DTXSID40904033 ;
Chemical and physical data
Formula	C28H35NO4
Molar mass	449.591 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C5\C=C4/C(=C3/[C@@H](c1ccc(\C=N\O)cc1)C[C@]2([C@@H](CC[C@@]2(OC)COC)[C@@H]3CC4)C)CC5;
	InChI InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,16,23-25,31H,8-13,15,17H2,1-3H3/b29-16+/t23-,24+,25-,27-,28+/m0/s1 ; Key:GJMNAFGEUJBOCE-MEQIQULJSA-N ;
	(what is this?) (verify)

Asoprisnil (INN; developmental code name J-867) is a synthetic, steroidal selective progesterone receptor modulator that was under development by Schering and TAP Pharmaceutical Products for the treatment of uterine fibroids.^[1] In 2005, phase III clinical trials were discontinued due to endometrial changes in patients.^[2]

References

^ DeManno D, Elger W, Garg R, et al. (2003). "Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy". Steroids. 68 (10–13): 1019–32. doi:10.1016/j.steroids.2003.09.008. PMID 14667995. S2CID 23074350.
^ Schering Interim Report Q1-3 2005

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.

Clinical data

ATC code	None
Identifiers
IUPAC name (8S,11R,13S,14S,17S)-11-[4-[(E)-hydroxyiminomethyl]phenyl]-17-methoxy-17-(methoxymethyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS Number	199396-76-4^N
PubChem CID	9577221
IUPHAR/BPS	2883
ChemSpider	7851660^Y
UNII	72W09924WP
KEGG	D02996^Y
ChEMBL	ChEMBL267431^Y
CompTox Dashboard (EPA)	DTXSID40904033
Chemical and physical data
Formula	C₂₈H₃₅NO₄
Molar mass	449.591 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C5\C=C4/C(=C3/[C@@H](c1ccc(\C=N\O)cc1)C[C@]2([C@@H](CC[C@@]2(OC)COC)[C@@H]3CC4)C)CC5
InChI InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,16,23-25,31H,8-13,15,17H2,1-3H3/b29-16+/t23-,24+,25-,27-,28+/m0/s1^Y Key:GJMNAFGEUJBOCE-MEQIQULJSA-N^Y
^NY (what is this?) (verify)