Wikipedia

Astromicin

Astromicin (INN; also frequently referenced in scientific journal articles as fortimicin A/B) is an aminoglycoside antibiotic. It is produced by Micromonospora olivasterospora (also named with additional o in olivoasterospora).[1][2]

Astromicin
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		IV
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 2-Amino-N-[(1S,2R,3R,4S,5S,6R)-4-amino-3-[(2R,3R,6S)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylacetamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H35N5O6
Molar mass405.496 g·mol−1
3D model (JSmol)
  • O=C(N(C)[C@@H]2[C@@H](OC)[C@@H](O)[C@H](N)[C@@H](O[C@H]1O[C@H]([C@@H](N)C)CC[C@H]1N)[C@@H]2O)CN
  • InChI=1S/C17H35N5O6/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+/m0/s1 checkY
  • Key:BIDUPMYXGFNAEJ-APGVDKLISA-N checkY
 ☒NcheckY (what is this?)  (verify)

References

edit
  1. ^ Itoh S, Odakura Y, Kase H, Satoh S, Takahashi K, Iida T, Shirahata K, Nakayama K (December 1984). "Biosynthesis of astromicin and related antibiotics. I. Biosynthetic studies by bioconversion experiments". The Journal of Antibiotics. 37 (12): 1664–9. doi:10.7164/antibiotics.37.1664. PMID 6526734.
  2. ^ Odakura Y, Kase H, Itoh S, Satoh S, Takasawa S, Takahashi K, Shirahata K, Nakayama K (December 1984). "Biosynthesis of astromicin and related antibiotics. II. Biosynthetic studies with blocked mutants of Micromonospora olivasterospora". The Journal of Antibiotics. 37 (12): 1670–80. doi:10.7164/antibiotics.37.1670. PMID 6526735.
 

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