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Atopobium

Atopobium is a genus of Actinomycetota, in the family Coriobacteriaceae. Atopobium species are anaerobic, Gram-positive rod-shaped or elliptical bacteria found as single elements or in pairs or short chains.

Atopobium
Scientific classification
Domain:
Bacteria
Phylum:
Actinomycetota
Class:
Coriobacteriia
Order:
Coriobacteriales
Family:
Atopobiaceae
Genus:
Atopobium

Collins and Wallbanks 1993
Type species
Atopobium minutum
(Hauduroy et al. 1937) Collins & Wallbanks 1993
Species[1]
  • A. deltae
  • "A. detroiti" Salimnia et al. 2008
  • A. fossor
  • "A. massiliense" Bordigoni et al. 2020
  • A. minutum

Atopobium vaginae was discovered in 1999.[2] This is a facultative anaerobic bacteria, which form small colonies on blood agar at 37 °C is also positive for acid phosphatase. This species has now been reclassified into the genus Fannyhessea following phylogenetic studies.

Clinical significance

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The genus Atopobium may be associated with bacterial vaginosis.[3][4][5]

The genus may play a role in the development of Colorectal cancer. While the genus has been reported as overrepresented in feces of patients,[6] A. minutum has conversely shown a mild apoptotic effect on cancer cells in vitro and has been suggested to be comparable to probiotic bacteria in regards to colorectal cancer.[7]


Phylogeny

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The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN)[8] and National Center for Biotechnology Information (NCBI).[9]

16S rRNA based LTP_08_2023[10][11][12] and 120 marker proteins based GTDB 08-RS214[13][14][15]
Atopobium

A. deltae Cools et al. 2014

A. fossor (Bailey and Love 1986) Kageyama et al. 1999

A. minutum (Hauduroy et al. 1937) Collins and Wallbanks 1993

See also

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References

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  1. ^ LPSN lpsn.dsmz.de
  2. ^ Rodriguez Jovita M, Collins MD, Sjödén B, Falsen E (1999). "Characterization of a novel Atopobium isolate from the human vagina: description of Atopobium vaginae sp. nov". Int J Syst Bacteriol. 49 (4): 1573–6. doi:10.1099/00207713-49-4-1573. PMID 10555338.
  3. ^ Verhelst R, Verstraelen H, Claeys G, Verschraegen G, Delanghe J, Van Simaey L, De Ganck C, Temmerman M, Vaneechoutte M (Apr 21, 2004). "Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis". BMC Microbiol. 4 (16): 1573–6. doi:10.1186/1471-2180-4-16. PMC 419343. PMID 15102329.
  4. ^ Burton JP, Devillard E, Cadieux PA, Hammond JA, Reid G (Apr 21, 2004). "Detection of Atopobium vaginae in postmenopausal women by cultivation-independent methods warrants further investigation". J Clin Microbiol. 42 (16): 1829–1831. doi:10.1128/jcm.42.4.1829-1831.2004. PMC 387601. PMID 15071062.
  5. ^ Burton JP, Chilcott CN, Al-Qumber M, Brooks HJ, Wilson D, Tagg JR, Devenish C (October 2005). "A preliminary survey of Atopobium vaginae in women attending the Dunedin gynaecology out-patients clinic: is the contribution of the hard-to-culturemicrobiota overlooked in gynaecological disorders?". The Australian and New Zealand Journal of Obstetrics and Gynaecology. 45 (5): 450–2. doi:10.1111/j.1479-828X.2005.00456.x. PMID 16171487. S2CID 44888920.
  6. ^ Ahn, J.; Sinha, R.; Pei, Z.; Dominianni, C.; Wu, J.; Shi, J.; Goedert, J. J.; Hayes, R. B.; Yang, L. (18 December 2013). "Human Gut Microbiome and Risk for Colorectal Cancer". J Natl Cancer Inst. 105 (24): 1907–1911. doi:10.1093/jnci/djt300. PMC 3866154. PMID 24316595.
  7. ^ Altonsy, M.O.; Andrews, S.C.; Tuohy, K.M. (28 February 2010). "Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enterophathogenic bacteria: mediation by the mitochondrial pathway". International Journal of Food Microbiology. 137 (2–3): 190–203. doi:10.1016/j.ijfoodmicro.2009.11.015. PMID 20036023.
  8. ^ Euzéby JP, Parte AC. "Atopobium". List of Prokaryotic names with Standing in Nomenclature (LPSN). Retrieved June 23, 2021.
  9. ^ Sayers; et al. "Atopobium". National Center for Biotechnology Information (NCBI) taxonomy database. Retrieved 2021-03-20.
  10. ^ "The LTP". Retrieved 20 November 2023.
  11. ^ "LTP_all tree in newick format". Retrieved 20 November 2023.
  12. ^ "LTP_08_2023 Release Notes" (PDF). Retrieved 20 November 2023.
  13. ^ "GTDB release 08-RS214". Genome Taxonomy Database. Retrieved 10 May 2023.
  14. ^ "bac120_r214.sp_label". Genome Taxonomy Database. Retrieved 10 May 2023.
  15. ^ "Taxon History". Genome Taxonomy Database. Retrieved 10 May 2023.
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