Atzeni (Italian: [atˈtsɛːni], Sardinian: [aˈtseni]) is a Sardinian surname. Notable people with the surname include:
- Alessandro Atzeni (born 1980), retired Italian footballer
- Andrea Atzeni (born 1991), professional Italian jockey based in England
- Giovanni Atzeni (born 1985, known as "Tittia"), Italian Palio jockey
- Sergio Atzeni (1952–1995, Italian writer)