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Aviv Regev

Aviv Regev (born 11 July 1971)[3] is a computational biologist and systems biologist and Executive Vice President and Head of Genentech Research and Early Development in Genentech/Roche.[4] She is a core member (on leave) at the Broad Institute of MIT and Harvard and professor (on leave) at the Department of Biology of the Massachusetts Institute of Technology.[5] Regev is a pioneer of single cell genomics and of computational and systems biology of gene regulatory circuits. She founded and leads the Human Cell Atlas project,[6] together with Sarah Teichmann.

Aviv Regev
Regev at the Intelligent Systems for Molecular Biology conference in 2017
Born (1971-07-11) July 11, 1971 (age 53)[3]
Alma materTel Aviv University (M.Sc., Ph.D.)
Awards
Scientific career
FieldsBioinformatics
Computational Biology
Institutions
Doctoral advisorEva Jablonka
Ehud Shapiro
Websitewww.gene.com/scientists/our-scientists/aviv-regev Edit this at Wikidata

Education

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Regev studied at the Adi Lautman Interdisciplinary Program for Outstanding Students of Tel Aviv University, where she completed her PhD under the supervision of Eva Jablonka,[7] and Ehud Shapiro.[8]

Career and research

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In 2020, Regev became the Head and Executive Vice President of Genentech Research and Early Development, based in South San Francisco, and a member of the extended Corporate Executive Committee of Roche.[9][10] Previously, she was a Core Institute Member (now on leave), Chair of the Faculty, Founding Director of the Klarman Cell Observatory and co-Director Cell Circuits Program at the Broad Institute of MIT and Harvard. She was also a professor in the Department of Biology at the Massachusetts Institute of Technology (now on leave), as well as an Investigator at the Howard Hughes Medical Institute. Regev's research[11] includes work on gene expression[12][13] (with Eran Segal and David Botstein), and the use of π-calculus to represent biochemical processes.[14][15][16] Regev's team has been a leading pioneer of single-cell genomics experimental and computational methods.[17] In 2014, she pitched the idea of the creation of Human Cell Atlas,[18] a project to describe all cell types in the human body. Regev founded the Human Cell Atlas together with Sarah Teichmann along with collaborators all over the world.[citation needed]

Single Cell Genomics

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Regev's lab pioneered the development and application of many of the key experimental and computational advances for single cell and spatial genomics, especially single cell RNA-Seq (scRNA-seq).

Awards and honors

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Regev is a fellow of the International Society of Computational Biology (ISCB) (2017),[19] a Helmholtz Fellow (2020),[20] and a fellow of the American Association for Cancer Research (AACR) (2021).[21] She is a member of the US National Academy of Sciences (NAS, elected 2019)[22] and of the US National Academy of Medicine (NAM, elected 2020).[23] She was elected as a foreign member of the Royal Society [24] and as an associate member of the European Molecular Biology Organization in 2024.[25]

References

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  1. ^ a b Sansom, C.; Morrison Mckay, B. J. (2008). Bourne, Philip E. (ed.). "ISCB Honors David Haussler and Aviv Regev". PLOS Computational Biology. 4 (7): e1000101. Bibcode:2008PLSCB...4E0101S. doi:10.1371/journal.pcbi.1000101. PMC 2536508. PMID 18795145.  
  2. ^ a b Fogg, Christiana N.; Kovats, Diane E.; Berger, Bonnie (2017). "2017 ISCB Innovator Award: Aviv Regev". PLOS Computational Biology. 13 (6): e1005558. Bibcode:2017PLSCB..13E5558F. doi:10.1371/journal.pcbi.1005558. ISSN 1553-7358. PMC 5493285. PMID 28665936.  
  3. ^ a b "Aviv Regev" (PDF). broadinstitute.org. Archived from the original (PDF) on 16 November 2017. Retrieved 2 December 2021.
  4. ^ GENENTECH EXECUTIVE COMMITTEE, accessed 6 August 2020.
  5. ^ "Aviv Regev at MIT". biology.mit.edu. Archived from the original on 6 April 2017. Retrieved 5 November 2017.
  6. ^ Nowogrodzki, Anna (5 July 2017). "How to build a human cell atlas". Nature. 547 (7661): 24–26. Bibcode:2017Natur.547...24N. doi:10.1038/547024a. PMID 28682347. S2CID 211067156.
  7. ^ Regev, A.; Lamb, M. J.; Jablonka, E. (1998). "The Role of DNA Methylation in Invertebrates: Developmental Regulation or Genome Defense?". Molecular Biology and Evolution. 15 (7): 880. doi:10.1093/oxfordjournals.molbev.a025992. ISSN 0737-4038.
  8. ^ Regev, A.; Shapiro, E. (2002). "Cellular abstractions: Cells as computation". Nature. 419 (6905): 343. Bibcode:2002Natur.419..343R. doi:10.1038/419343a. PMC 3842595. PMID 12353013.  
  9. ^ Taylor, Nick Paul (11 May 2020). "Genentech lures Regev from Broad Institute to lead research and early development". fiercebiotech.com. Retrieved 25 May 2020.
  10. ^ "Changes to the Roche Enlarged Corporate Executive Committee" (Press release). Basel, Switzerland: F. Hoffmann-La Roche Ltd. globenewswire. 11 May 2020. Retrieved 25 May 2020.
  11. ^ Search Results for author Regev A on PubMed.
  12. ^ Segal, E.; Shapira, M.; Regev, A.; Pe'er, D.; Botstein, D.; Koller, D.; Friedman, N. (2003). "Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data". Nature Genetics. 34 (2): 166–176. doi:10.1038/ng1165. PMID 12740579. S2CID 6146032.
  13. ^ Segal, E.; Friedman, N.; Koller, D.; Regev, A. (2004). "A module map showing conditional activity of expression modules in cancer". Nature Genetics. 36 (10): 1090–1098. doi:10.1038/ng1434. PMC 2271138. PMID 15448693.  
  14. ^ Regev, A.; Silverman, W.; Shapiro, E. (2001). "Representation and simulation of biochemical processes using the pi-calculus process algebra". Pacific Symposium on Biocomputing: 459–470. doi:10.1142/9789814447362_0045. ISBN 978-981-02-4515-3. PMID 11262964.
  15. ^ Priami, C.; et al. (2001). "Application of a stochastic name-passing calculus to representation and simulation of molecular processes" (PDF). Information Processing Letters. 80: 25–31. doi:10.1016/S0020-0190(01)00214-9.  
  16. ^ Study provides insight into regenerative potential of prostate gland, News Medical, accessed 4 May 2020.
  17. ^ "Aviv Regev". HHMI.org. Retrieved 11 May 2020.
  18. ^ The Human Cell Atlas – Aviv Regev, August 2014, retrieved 30 May 2022
  19. ^ "2017 ISCB Innovator Award: Aviv Regev". www.iscb.org. Retrieved 14 March 2022.
  20. ^ "Event – Helmholtz Zentrum München". www.helmholtz-munich.de. Retrieved 14 March 2022.
  21. ^ "Aviv Regev, PhD, FAACR | Scientific Awards | AACR". American Association for Cancer Research (AACR). Retrieved 14 March 2022.
  22. ^ "Aviv Regev". www.nasonline.org. Retrieved 14 March 2022.
  23. ^ "National Academy of Medicine Elects 100 New Members". National Academy of Medicine. 19 October 2020. Retrieved 14 March 2022.
  24. ^ "Outstanding scientists elected as Fellows of the Royal Society".
  25. ^ "EMBO elects 2024 members".
  26. ^ "Aviv Regev: Can AI Help Develop New Medicines". 9 August 2024.
  27. ^ "Discover the laureates of the 25th L'Oréal-UNESCO For Women in Science International Awards | UNESCO". www.unesco.org. Retrieved 2 June 2023.
  28. ^ "New Members". American Academy of Arts & Sciences. Retrieved 30 May 2022.
  29. ^ "The Events Calendar".
  30. ^ "Press Release – 2022 HFSP Nakasone Award".
  31. ^ Foppa, Carolin Arndt (22 November 2021). "Pioneer in bioinformatics receives ETH Honorary doctorate". bsse.ethz.ch. Retrieved 18 March 2022.
  32. ^ "Ernst Schering Prize 2021 – Schering Stiftung". Retrieved 18 March 2022.
  33. ^ "James Prize in Science and Technology Integration". www.nasonline.org. Retrieved 18 March 2022.
  34. ^ Snyder, Bill (28 April 2021). "Regev receives Vanderbilt Prize in Biomedical Science". Vanderbilt University. Retrieved 18 March 2022.
  35. ^ "Award Ceremony for the 25th Keio Medical Science Prize". keio.ac.jp. Retrieved 22 December 2020.
  36. ^ "Announcement of the 25th Keio Medical Science Prize – News – Keio University Medical Science Fund". www.ms-fund.keio.ac.jp. Retrieved 18 March 2022.
  37. ^ "Aviv Regev, PhD, FAACR | Scientific Awards | AACR". American Association for Cancer Research (AACR). Retrieved 18 March 2022.
  38. ^ "2020 FNIH Lurie Prize in Biomedical Sciences Winner Pioneered Innovative Techniques to Shed New Light on Human Health | The Foundation for the National Institutes of Health". fnih.org. 18 June 2020. Retrieved 18 March 2022.
  39. ^ Wimmer, Doris. "Aviv Regev". ESHG Conference 2020. Retrieved 14 March 2022.
  40. ^ "Kraft Prize Symposium". Massachusetts General Hospital. Retrieved 14 March 2022.
  41. ^ "Past Recipients". www.faseb.org. Retrieved 14 March 2022.
  42. ^ "2019 NAS Election". nasonline.org. Retrieved 30 April 2019.
  43. ^ "Weatherall Lectures — MRC Weatherall Institute of Molecular Medicine". www.imm.ox.ac.uk. Retrieved 14 March 2022.
  44. ^ "The Harvey Society: Series 113, Lecture 5". harveysociety.org. Retrieved 14 March 2022.
  45. ^ "MIT's Aviv Regev to present annual McCormick Lecture Feb. 1". News Center (in Samoan). Retrieved 14 March 2022.
  46. ^ "2017 Prize Winners". Memorial Sloan Kettering Cancer Center. Retrieved 12 December 2017.
  47. ^ "February 09, 2017: ISCB Announces 2017 Award Recipients". iscb.org. Retrieved 10 February 2017.
  48. ^ "Regev recognized for rigorous integration of experimental and computational approaches". www.asbmb.org. Retrieved 14 March 2022.
  49. ^ Dynamic single-cell imaging of direct reprogramming reveals an early specifying event – Nature Biotechnology: Aviv Regev, Ph.D. – Career Awards at the Scientific Interface; Ab initio reconstruction of cell type–specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs – Nature Biotechnology: Aviv Regev, Ph.D. – Career Awards at the Scientific Interface.
  50. ^ "Three faculty win '08 NIH Pioneer Awards". MIT News | Massachusetts Institute of Technology. 22 September 2008. Retrieved 6 March 2022.
  51. ^ "2008 NIH Director's Pioneer Award". Archived from the original on 30 July 2019. Retrieved 30 July 2019.
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