Avizafone[1] (Pro-Diazepam) is a water-soluble prodrug of the benzodiazepine derivative diazepam. It can be administered intramuscularly.
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Routes of administration | Intramuscular injection |
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Formula | C22H27ClN4O3 |
Molar mass | 430.93 g·mol−1 |
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Avizafone is metabolised by enzymes in the blood to form the active drug diazepam. It is used mainly as an antidote to poisoning with organophosphate nerve agents.[2][3][4]
See also
editReferences
edit- ^ GB 1517164
- ^ Karlsson B, Lindgren B, Millquist E, Sandberg M, Sellström A (April 1990). "On the use of diazepam and pro-diazepam (2-benzoyl-4-chloro-N-methyl-N-lysylglycin anilide), as adjunct antidotes in the treatment of organophosphorus intoxication in the guinea-pig". The Journal of Pharmacy and Pharmacology. 42 (4): 247–51. doi:10.1111/j.2042-7158.1990.tb05401.x. PMID 1974291. S2CID 32369013.
- ^ Lallement G, Renault F, Baubichon D, Peoc'h M, Burckhart MF, Galonnier M, et al. (October 2000). "Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics". Archives of Toxicology. 74 (8): 480–6. doi:10.1007/s002040000146. PMID 11097386. S2CID 22292597.
- ^ Taysse L, Calvet JH, Buée J, Christin D, Delamanche S, Breton P (June 2003). "Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose". Toxicology. 188 (2–3): 197–209. doi:10.1016/s0300-483x(03)00086-6. PMID 12767691.