Axelrad is a surname. Notable people with the surname include:
- Albert S. Axelrad (born 1938), American rabbi
- Édouard Axelrad (1918–2006), French writer
- John Axelrad, editor of films including We Own the Night
- Nancy Axelrad, publisher and author of some of the Nancy Drew series of books
- Penina Axelrad, American aerospace engineer
- Vicki Lawrence (b. 1949), born Vicki Ann Axelrad, American actress, comedian, and singer
- Ali Axelrad, born Alison Axelrad, American Actress and singer.