BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene.[5][6][7]

BAG5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBAG5, BAG-5, BCL2 associated athanogene 5, BAG cochaperone 5, CMD2F
External IDsOMIM: 603885; MGI: 1917619; HomoloGene: 3584; GeneCards: BAG5; OMA:BAG5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004873
NM_001015048
NM_001015049

NM_027404
NM_001324480
NM_001324481
NM_001324482

RefSeq (protein)

NP_001015048
NP_001015049
NP_004864

NP_001311409
NP_001311410
NP_001311411
NP_081680

Location (UCSC)Chr 14: 103.56 – 103.56 MbChr 12: 111.68 – 111.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166170Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049792Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takayama S, Xie Z, Reed JC (Feb 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J Biol Chem. 274 (2): 781–6. doi:10.1074/jbc.274.2.781. PMID 9873016.
  6. ^ Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM (Dec 2004). "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration". Neuron. 44 (6): 931–45. doi:10.1016/j.neuron.2004.11.026. PMID 15603737.
  7. ^ a b "Entrez Gene: BAG5 BCL2-associated athanogene 5".
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Further reading

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