BANCR

BRAF-activated non-protein coding RNA is a noncoding RNA that in humans is encoded by the BANCR gene. Long non-coding RNAs (lncRNAs) are involved in the intricate network of cancer and contribute significantly to tumorigenesis and progression. BRAF activated non-coding RNA (BANCR), a 693-bp four-exon transcript, was first identified in 2012 as an oncogenic long non-coding RNA in BRAFV600E melanomas cells and was found to be associated with melanoma cell migration. Apart from melanoma, growing evidence has implicated BANCR in the development and progression of a variety of other human malignancies, including retinoblastoma, lung cancer, and gastric cancer, since its discovery. The pattern of expression of BANCR varies according to the kind of cancer, acting as either a tumour suppressor or an accelerator. Functional BANCR may be a useful biomarker for cancer diagnosis and prognosis assessment. BANCR-targeted therapy may also prove to be a promising new treatment option for human cancers.

BANCR
Identifiers
Aliases	BANCR, LINC00586, BRAF-activated non-protein coding RNA
External IDs	GeneCards: BANCR; OMA:BANCR - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q21.11-q21.12 Start 69,296,678 bp End 69,311,111 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle buccal mucosa cell myocardium of left ventricle smooth muscle tissue right ventricle retinal pigment epithelium apex of heart islet of Langerhans right auricle right lung n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 100885775 n/a Ensembl ENSG00000278910 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 9: 69.3 – 69.31 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Further reading

• Ross JF, Dan EW, Kun Q, Nicholas M, Joanna K, Markus K, Paul AK (2012). "BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration". Genome Res. 22 (6): 1006–1014. doi:10.1101/gr.140061.112. PMC 3371703. PMID 22581800.
• Sherrill JD, Kiran KC, Blanchard C, Stucke EM, Kemme KA, Collins MH, Abonia JP, Putnam PE, Mukkada VA, Kaul A, Kocoshis SA, Kushner JP, Plassard AJ, Karns RA, Dexheimer PJ, Aronow BJ, Rothenberg ME (2014). "Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing". Genes Immun. 15 (6): 361–9. doi:10.1038/gene.2014.27. PMC 4156528. PMID 24920534.
• Jiang W, Zhang D, Xu B, Wu Z, Liu S, Zhang L, Tian Y, Han X, Tian D (2015). "Long non-coding RNA BANCR promotes proliferation and migration of lung carcinoma via MAPK pathways". Biomed. Pharmacother. 69: 90–5. doi:10.1016/j.biopha.2014.11.027. PMID 25661343.
• Su S, Gao J, Wang T, Wang J, Li H, Wang Z (2015). "Long non-coding RNA BANCR regulates growth and metastasis and is associated with poor prognosis in retinoblastoma". Tumour Biol. 36 (9): 7205–11. doi:10.1007/s13277-015-3413-3. PMID 25894373. S2CID 23350523.
• Shi Y, Liu Y, Wang J, Jie D, Yun T, Li W, Yan L, Wang K, Feng J (2015). "Downregulated Long Noncoding RNA BANCR Promotes the Proliferation of Colorectal Cancer Cells via Downregualtion of p21 Expression". PLOS ONE. 10 (4): e0122679. Bibcode:2015PLoSO..1022679S. doi:10.1371/journal.pone.0122679. PMC 4415816. PMID 25928067.
• Li L, Zhang L, Zhang Y, Zhou F (2015). "Increased expression of LncRNA BANCR is associated with clinical progression and poor prognosis in gastric cancer". Biomed. Pharmacother. 72: 109–12. doi:10.1016/j.biopha.2015.04.007. PMID 26054683.
• Zhang ZX, Liu ZQ, Jiang B, Lu XY, Ning XF, Yuan CT, Wang AL (2015). "BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-κB1". Biochem. Biophys. Res. Commun. 465 (2): 225–31. doi:10.1016/j.bbrc.2015.07.158. PMID 26248136.
• Li AX, Xin WQ, Ma CG (2015). "Fentanyl inhibits the invasion and migration of colorectal cancer cells via inhibiting the negative regulation of Ets-1 on BANCR". Biochem. Biophys. Res. Commun. 465 (3): 594–600. doi:10.1016/j.bbrc.2015.08.068. PMID 26296467.
• Liu Z, Yang T, Xu Z, Cao X (2016). "Upregulation of the long non-coding RNA BANCR correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma". Biomed. Pharmacother. 82: 406–12. doi:10.1016/j.biopha.2016.05.014. PMID 27470379. S2CID 36882011.