BCL2L10

Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.

BCL2L10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B4S
Identifiers
Aliases	BCL2L10, BCL-B, Boo, Diva, bcl2-L-10, BCL2 like 10
External IDs	OMIM: 606910; MGI: 1330841; HomoloGene: 8396; GeneCards: BCL2L10; OMA:BCL2L10 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.2 Start 52,109,263 bp End 52,112,775 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 D Start 75,255,040 bp End 75,258,931 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver skin of abdomen skin of leg right adrenal gland right adrenal cortex left adrenal gland mucosa of esophagus human kidney left adrenal cortex nucleus accumbens Top expressed in secondary oocyte blastocyst primary oocyte zygote meninges morula ovary cumulus cell white adipose tissue subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding caspase binding protein homodimerization activity protein heterodimerization activity Cellular component nucleus integral component of membrane cytosol nuclear membrane mitochondrion membrane mitochondrial outer membrane Biological process apoptotic process regulation of apoptotic process negative regulation of apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process female gamete generation spermatogenesis intrinsic apoptotic signaling pathway in response to DNA damage extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10017 12049 Ensembl ENSG00000137875 ENSMUSG00000032191 UniProt Q9HD36 Q9Z0F3 RefSeq (mRNA) NM_001306168 NM_020396 NM_013479 RefSeq (protein) NP_001293097 NP_065129 NP_038507 Location (UCSC) Chr 15: 52.11 – 52.11 Mb Chr 9: 75.26 – 75.26 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus preventing caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic pathway.

Further reading

• van Oirschot JT (1999). "Diva vaccines that reduce virus transmission". J. Biotechnol. 73 (2–3): 195–205. doi:10.1016/S0168-1656(99)00121-2. PMID 10486928.
• Pan G, O'Rourke K, Dixit VM (1998). "Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex". J. Biol. Chem. 273 (10): 5841–5. doi:10.1074/jbc.273.10.5841. PMID 9488720.
• Ke N, Godzik A, Reed JC (2001). "Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak". J. Biol. Chem. 276 (16): 12481–4. doi:10.1074/jbc.C000871200. PMID 11278245.
• Naumann U, Weit S, Wischhusen J, Weller M (2001). "Diva/Boo is a negative regulator of cell death in human glioma cells". FEBS Lett. 505 (1): 23–6. doi:10.1016/S0014-5793(01)02768-5. PMID 11557035.
• Aouacheria A, Arnaud E, Venet S, et al. (2001). "Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis". Oncogene. 20 (41): 5846–55. doi:10.1038/sj.onc.1204740. PMID 11593390.
• Zhang H, Holzgreve W, De Geyter C (2002). "Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway". Hum. Mol. Genet. 10 (21): 2329–39. doi:10.1093/hmg/10.21.2329. PMID 11689480.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Li Z, Takeuchi S, Ohara N, Maruo T (2003). "Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical squamous carcinoma". Int. J. Clin. Oncol. 8 (2): 83–9. doi:10.1007/s101470300015. PMID 12720100. S2CID 24180107.
• Kang Y, Lee DC, Han J, et al. (2007). "NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling". Biochem. Biophys. Res. Commun. 359 (1): 76–82. doi:10.1016/j.bbrc.2007.05.090. PMID 17532299.
• Guillemin Y, Lalle P, Gillet G, et al. (2009). "Oocytes and early embryos selectively express the survival factor BCL2L10". J. Mol. Med. 87 (9): 923–40. doi:10.1007/s00109-009-0495-7. PMID 19551325. S2CID 23491033.

External links

• BCL2L10 human gene location in the UCSC Genome Browser.
• BCL2L10 human gene details in the UCSC Genome Browser.