BET1

BET1 homolog is a protein that in humans is encoded by the BET1 gene.

BET1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EGX
Identifiers
Aliases	BET1, HBet1 golgi vesicular membrane trafficking protein
External IDs	OMIM: 605456; MGI: 1343104; HomoloGene: 38108; GeneCards: BET1; OMA:BET1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q21.3 Start 93,962,762 bp End 94,004,382 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 A1 Start 4,076,899 bp End 4,086,972 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas Achilles tendon placenta endometrium corpus epididymis anterior pituitary monocyte right adrenal gland right adrenal cortex left adrenal gland Top expressed in gastrula decidua right kidney ventricular zone lip seminal vesicula lacrimal gland otic placode morula parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding syntaxin binding SNAP receptor activity Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane Golgi cisterna Golgi membrane cis-Golgi network transport vesicle SNARE complex endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment membrane Golgi trans cisterna integral component of Golgi membrane Biological process vesicle fusion with Golgi apparatus endoplasmic reticulum to Golgi vesicle-mediated transport COPII vesicle coating protein transport vesicle-mediated transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10282 12068 Ensembl ENSG00000105829 ENSMUSG00000032757 UniProt O15155 O35623 RefSeq (mRNA) NM_005868 NM_001317739 NM_009748 RefSeq (protein) NP_001304668 NP_005859 NP_033878 Location (UCSC) Chr 7: 93.96 – 94 Mb Chr 6: 4.08 – 4.09 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has not been determined.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang T, Hong W (2001). "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport". J. Biol. Chem. 276 (29): 27480–7. doi:10.1074/jbc.M102786200. PMID 11323436.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
• Hay JC, Hirling H, Scheller RH (1996). "Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus". J. Biol. Chem. 271 (10): 5671–9. doi:10.1074/jbc.271.10.5671. PMID 8621431.

External links

• BET1 human gene location in the UCSC Genome Browser.
• BET1 human gene details in the UCSC Genome Browser.