BICD1

Bicaudal D cargo adaptor 1 is a protein that in humans is encoded by the BICD1 gene.

BICD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YTD
Identifiers
Aliases	BICD1, BICD, BICD cargo adaptor 1, bic-D 1
External IDs	OMIM: 602204; MGI: 1101760; HomoloGene: 37518; GeneCards: BICD1; OMA:BICD1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p11.21 Start 32,106,835 bp End 32,383,633 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 G3 Start 149,310,384 bp End 149,464,827 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone sural nerve ganglionic eminence cerebellar vermis right uterine tube caput epididymis trigeminal ganglion spinal ganglia left ovary paraflocculus of cerebellum Top expressed in sciatic nerve mammillary body ventromedial nucleus lateral septal nucleus lateral hypothalamus substantia nigra lobe of cerebellum lateral geniculate nucleus ventral tegmental area habenula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function dynactin binding structural constituent of cytoskeleton proteinase activated receptor binding protein binding cytoskeletal anchor activity dynein complex binding protein kinase binding dynein intermediate chain binding Cellular component Golgi apparatus membrane host cell viral assembly compartment trans-Golgi network tubulin complex perinuclear region of cytoplasm cytoplasmic microtubule cytoskeleton cytoplasmic vesicle cytosol centrosome Biological process protein localization to organelle regulation of proteinase activated receptor activity positive regulation of receptor-mediated endocytosis RNA processing microtubule anchoring at microtubule organizing center negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway negative regulation of phospholipase C activity anatomical structure morphogenesis intracellular mRNA localization minus-end-directed organelle transport along microtubule viral process stress granule assembly transport regulation of microtubule cytoskeleton organization positive regulation of protein localization to centrosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 636 12121 Ensembl ENSG00000151746 ENSMUSG00000003452 UniProt Q96G01 Q8BR07 RefSeq (mRNA) NM_001003398 NM_001714 NM_001354186 NM_001354187 NM_001354188 NM_001354189 NM_001363603 NM_001112796 NM_009753 RefSeq (protein) NP_001003398 NP_001705 NP_001341115 NP_001341116 NP_001341117 NP_001341118 NP_001350532 NP_001106267 NP_033883 Location (UCSC) Chr 12: 32.11 – 32.38 Mb Chr 6: 149.31 – 149.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.

Interactions

BICD1 has been shown to interact with RAB6A.

External links

• Human BICD1 genome location and BICD1 gene details page in the UCSC Genome Browser.

Further reading

• Barr FA, Short B (August 2003). "Golgins in the structure and dynamics of the Golgi apparatus". Current Opinion in Cell Biology. 15 (4): 405–13. doi:10.1016/S0955-0674(03)00054-1. PMID 12892780.
• Claussen M, Suter B (November 2005). "BicD-dependent localization processes: from Drosophilia development to human cell biology". Annals of Anatomy - Anatomischer Anzeiger. 187 (5–6): 539–53. doi:10.1016/j.aanat.2005.07.004. PMID 16320833.
• Baens M, Aerssens J, van Zand K, Van den Berghe H, Marynen P (September 1995). "Isolation and regional assignment of human chromosome 12p cDNAs". Genomics. 29 (1): 44–52. doi:10.1006/geno.1995.1213. PMID 8530100.
• Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (October 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. Bibcode:2002CBio...12.1792S. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177. S2CID 14031165.
• Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140.
• Tomsig JL, Snyder SL, Creutz CE (Mar 2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". The Journal of Biological Chemistry. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Fuchs E, Short B, Barr FA (2006). "Assay and Properties of Rab6 Interaction with Dynein–Dynactin Complexes". GTPases Regulating Membrane Targeting and Fusion. Methods in Enzymology. Vol. 403. pp. 607–18. doi:10.1016/S0076-6879(05)03053-3. ISBN 978-0-12-182808-0. PMID 16473624.
• Moorhead AR, Rzomp KA, Scidmore MA (Feb 2007). "The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner". Infection and Immunity. 75 (2): 781–91. doi:10.1128/IAI.01447-06. PMC 1828475. PMID 17101644.
• Fumoto K, Hoogenraad CC, Kikuchi A (December 2006). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome". The EMBO Journal. 25 (24): 5670–82. doi:10.1038/sj.emboj.7601459. PMC 1698904. PMID 17139249.
• Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA (Oct 2007). "A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells". Experimental Cell Research. 313 (16): 3408–20. doi:10.1016/j.yexcr.2007.05.032. PMID 17707369.