BRMS1

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.

BRMS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XUS, 4AUV
Identifiers
Aliases	BRMS1, breast cancer metastasis suppressor 1, transcriptional repressor and anoikis regulator, BRMS1 transcriptional repressor and anoikis regulator
External IDs	OMIM: 606259; MGI: 2388804; HomoloGene: 32260; GeneCards: BRMS1; OMA:BRMS1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.2 Start 66,337,333 bp End 66,345,125 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 5,091,382 bp End 5,099,945 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mucosa of transverse colon monocyte skin of leg skin of abdomen body of stomach body of pancreas sural nerve minor salivary glands mucosa of esophagus Top expressed in spermatid blastocyst yolk sac morula lip right kidney granulocyte embryo embryo neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone deacetylase binding protein binding NF-kappaB binding histone deacetylase activity Cellular component cytoplasm Sin3-type complex nucleus nucleoplasm Biological process positive regulation of protein deacetylation positive regulation of anoikis negative regulation of transcription, DNA-templated negative regulation of NF-kappaB transcription factor activity negative regulation of transcription by RNA polymerase II histone deacetylation regulation of transcription, DNA-templated transcription, DNA-templated apoptotic process regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25855 107392 Ensembl ENSG00000174744 ENSMUSG00000080268 UniProt Q9HCU9 Q99N20 RefSeq (mRNA) NM_015399 NM_001024957 NM_001024958 NM_134155 NM_001374047 NM_001374048 RefSeq (protein) NP_001020128 NP_056214 NP_598916 NP_001360976 NP_001360977 Location (UCSC) Chr 11: 66.34 – 66.35 Mb Chr 19: 5.09 – 5.1 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.

External links

• Human BRMS1 genome location and BRMS1 gene details page in the UCSC Genome Browser.

Further reading

• Meehan WJ, Welch DR (2003). "Breast cancer metastasis suppressor 1: update". Clin. Exp. Metastasis. 20 (1): 45–50. doi:10.1023/A:1022542519586. PMID 12650606. S2CID 26142383.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Samant RS, Debies MT, Shevde LA, et al. (2002). "Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1)". Int. J. Cancer. 97 (1): 15–20. doi:10.1002/ijc.1569. PMID 11774238. S2CID 19747938.
• Shevde LA, Samant RS, Goldberg SF, et al. (2002). "Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1". Exp. Cell Res. 273 (2): 229–39. doi:10.1006/excr.2001.5452. PMID 11822878.
• Janneau JL, Maldonado-Estrada J, Tachdjian G, et al. (2002). "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells". J. Clin. Endocrinol. Metab. 87 (11): 5336–9. doi:10.1210/jc.2002-021093. PMID 12414911.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Meehan WJ, Samant RS, Hopper JE, et al. (2004). "Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription". J. Biol. Chem. 279 (2): 1562–9. doi:10.1074/jbc.M307969200. PMID 14581478.
• Cicek M, Samant RS, Kinter M, et al. (2004). "Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells". Clin. Exp. Metastasis. 21 (2): 149–57. doi:10.1023/B:CLIN.0000024729.19084.f0. PMID 15168732. S2CID 19383717.
• Nikolaev AY, Papanikolaou NA, Li M, et al. (2004). "Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex". Biochem. Biophys. Res. Commun. 323 (4): 1216–22. doi:10.1016/j.bbrc.2004.08.227. PMID 15451426.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stark AM, Tongers K, Maass N, et al. (2005). "Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases". J. Cancer Res. Clin. Oncol. 131 (3): 191–8. doi:10.1007/s00432-004-0629-9. PMID 15592684. S2CID 12411341.
• DeWald DB, Torabinejad J, Samant RS, et al. (2005). "Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells". Cancer Res. 65 (3): 713–7. doi:10.1158/0008-5472.713.65.3. PMID 15705865. S2CID 24886361.
• Cicek M, Fukuyama R, Welch DR, et al. (2005). "Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity". Cancer Res. 65 (9): 3586–95. doi:10.1158/0008-5472.CAN-04-3139. PMID 15867352.
• Hurst DR, Mehta A, Moore BP, et al. (2006). "Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone". Biochem. Biophys. Res. Commun. 348 (4): 1429–35. doi:10.1016/j.bbrc.2006.08.005. PMC 1557677. PMID 16919237.
• Samant RS, Clark DW, Fillmore RA, et al. (2007). "Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation". Mol. Cancer. 6: 6. doi:10.1186/1476-4598-6-6. PMC 1796551. PMID 17227585.
• Rivera J, Megias D, Bravo J (2007). "Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1". J. Proteome Res. 6 (10): 4006–18. doi:10.1021/pr0703167. PMID 17854218.