Baldassare is a masculine Italian given name. Notable people with the name include:
- Baldassare Aloisi (1578–1638), Italian history and portrait painter and engraver
- Baldassare Bianchi (1612–1679), Italian painter
- Baldassare Castiglione (1478–1529), Italian Renaissance writer
- Baldassare Cittadella (1603–1651), Italian Jesuit
- Baldassare Croce (1558–1628), Italian painter
- Baldassare d'Anna (circa 1560–1600), Italian painter
- Baldassare Di Maggio (born 1954), Sicilian Mafioso
- Baldassare Donato (circa 1525–1603), Italian composer and singer
- Baldassare Ferri (1610–1680), Italian singer
- Baldassare Forestiere (1879–1946), Italian-American founder of the Forestiere Underground Gardens
- Baldassare Franceschini (1611–1689), Italian Baroque painter
- Baldassare Gabbugiani (18th century), Italian engraver
- Baldassare Galuppi (1706–1785), Venetian composer
- Baldassare Peruzzi (1481–1537), Italian architect and painter
- Baldassare Verazzi (1819–1886), Italian painter