Acquired progressive lymphangioma, also known as benign lymphangioendothelioma is a group of lymphangiomas that occur anywhere in young individuals, grow slowly, and present as bruise-like lesions or erythematous macules.[1]: 597 Acquired progressive lymphangioma may develop following radiation therapy, surgery, trauma, inflammation, and tick bites. The treatment of choice is complete surgical excision.
| Acquired progressive lymphangioma | |
|---|---|
| Other names | Benign lymphangioendothelioma |
| Specialty | Oncology  |
Signs and symptoms
editAcquired progressive lymphangioma appears as a slowly growing erythaematous to brownish, bruise-like, macule, plaque, or nodule typically located on the legs, head or neck.[2] The lesions are usually asymptomatic.[3]
Causes
editAcquired progressive lymphangioma has been known to develop after radiation therapy,[4] surgery,[5] trauma,[6] femoral arteriography,[7] inflammation,[8] and tick bites.[9]
Mechanism
editBecause acquired progressive lymphangioma has been described following various traumas, it is thought to be a response to various inflammatory stimuli rather than a real neoplasm.[10]
Another possible pathogenic explanation is hormonal stimulation, as quickly growing lesions have been observed in numerous pubescent and prepubescent individuals.[11]
Finally, another idea proposed is that acquired progressive lymphangioma represents a complicated vascular hamartoma with three components: lymphatic vessels, blood vessels, and smooth muscle.[12]
Diagnosis
editAcquired progressive lymphangioma has thin-walled endothelial-lined gaps interspersed between collagen strands.[2] Endothelial cells show positive staining for lymphatic markers as podoplanin (D2-40), LYVE-1, and PROX-1. Additionally, the cells have variable levels of factor VIII, Ulex europaeus agglutinin I, CD31, and CD34.[10]
Treatment
editAcquired progressive lymphangioma is treated by complete surgical excision.[2]
See also
editReferences
edit- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- ^ a b c Jones, Edward Wilson; Winkelmann, R.K.; Zachary, C.B.; Reda, Ashraf M. (1990). "Benign lymphangioendothelioma". Journal of the American Academy of Dermatology. 23 (2). Elsevier BV: 229–235. doi:10.1016/0190-9622(90)70203-t. ISSN 0190-9622. PMID 2212118.
- ^ Yamada, Sohsuke; Yamada, Yoko; Kobayashi, Miwa; Hino, Ryosuke; Nawata, Aya; Noguchi, Hirotsugu; Nakamura, Motonobu; Nakayama, Toshiyuki (2014). "Post-mastectomy benign lymphangioendothelioma of the skin following chronic lymphedema for breast carcinoma: a teaching case mimicking low-grade angiosarcoma and masquerading as Stewart-Treves syndrome". Diagnostic Pathology. 9 (1): 197. doi:10.1186/s13000-014-0197-5. ISSN 1746-1596. PMC 4215009. PMID 25358645.
- ^ Rosso, R.; Gianelli, U.; Carnevali, L. (1995). "Acquired progressive lymphangioma of the skin following radiotherapy for breast carcinoma". Journal of Cutaneous Pathology. 22 (2). Wiley: 164–167. doi:10.1111/j.1600-0560.1995.tb01401.x. ISSN 0303-6987. PMID 7560351.
- ^ Grunwald, Marcelo H.; Amichai, Boaz; Avinoach, Ilana (1997). "Acquired progressive lymphangioma". Journal of the American Academy of Dermatology. 37 (4). Elsevier BV: 656–657. doi:10.1016/s0190-9622(97)70192-0. ISSN 0190-9622. PMID 9344213.
- ^ Watanabe, Makoto; Kishiyama, Kazunori; Ohkawara, Akira (1983). "Acquired progressive lymphangioma". Journal of the American Academy of Dermatology. 8 (5). Elsevier BV: 663–667. doi:10.1016/s0190-9622(83)70076-9. ISSN 0190-9622. PMID 6863623.
- ^ Kato, H.; Kadoya, A. (1996). "Acquired progressive lymphangioma occurring following femoral arteriography". Clinical and Experimental Dermatology. 21 (2): 159–162. doi:10.1111/j.1365-2230.1996.tb00044.x. PMID 8759209.
- ^ Herron, G. Scott; Rouse, Robert V.; Kosek, Jon C.; Smoller, Bruce R.; Egbert, Barbara M. (1994). "Benign lymphangioendothelioma". Journal of the American Academy of Dermatology. 31 (2). Elsevier BV: 362–368. doi:10.1016/s0190-9622(94)70173-3. ISSN 0190-9622. PMID 7518477.
- ^ Wilmera, Axel; Kaatza, Martin; Mentzelb, Thomas; Wollinaa, Uwe (1998). "Lymphangioendothelioma after a tick bite". Journal of the American Academy of Dermatology. 39 (1): 126–128. doi:10.1016/S0190-9622(98)70416-5. PMID 9674411.
- ^ a b Vittal, Naveen kumar (2016). "Benign Lymphangioendothelioma — A Case Report". Journal of Clinical and Diagnostic Research. 10 (1). JCDR Research and Publications: WD01-2. doi:10.7860/jcdr/2016/15664.7155. ISSN 2249-782X. PMC 4740690. PMID 26894162.
- ^ Tadaki, Takayoshi (1988-05-01). "Acquired Progressive Lymphangioma as a Flat Erythematous Patch on the Abdominal Wall of a Child". Archives of Dermatology. 124 (5): 699. doi:10.1001/archderm.1988.01670050043017. ISSN 0003-987X. PMID 2966611.
- ^ Zhu, Wen-Yuan; Penneys, Neal S.; Reyes, Blas; Khatib, Ziad; Schachner, Lawrence (1991). "Acquired progressive lymphangioma". Journal of the American Academy of Dermatology. 24 (5). Elsevier BV: 813–815. doi:10.1016/0190-9622(91)70120-q. ISSN 0190-9622. PMID 2050845.
Further reading
edit- Lu, Wei; Cao, Yan; Zeng, Fanhua; Chen, Chun; Yang, Zhenyu; Qi, Zuoliang; Yang, Xiaonan (2023). "Surgical Treatment for Benign Lymphangioendothelioma After Two Incomplete Excisions: A Case Report and Literature Review". Clinical, Cosmetic and Investigational Dermatology. 16. Informa UK Limited: 2697–2719. doi:10.2147/ccid.s420019. ISSN 1178-7015. PMC 10544170.
- Guillou, Louis; Fletcher, Christopher D. M. (2000). "Benign Lymphangioendothelioma (Acquired Progressive Lymphangioma): A Lesion Not to Be Confused With Well-Differentiated Angiosarcoma and Patch Stage Kaposi's Sarcoma". The American Journal of Surgical Pathology. 24 (8). Ovid Technologies (Wolters Kluwer Health): 1047–1057. doi:10.1097/00000478-200008000-00002. ISSN 0147-5185.