Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene.[5][6] The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins.[7]

PROX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPROX1, prospero homeobox 1
External IDsOMIM: 601546; MGI: 97772; HomoloGene: 2069; GeneCards: PROX1; OMA:PROX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270616
NM_002763

NM_008937
NM_001360827

RefSeq (protein)

NP_001257545
NP_002754

NP_032963
NP_001347756

Location (UCSC)Chr 1: 213.98 – 214.04 MbChr 1: 189.85 – 189.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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PROX1 has been shown to interact with EP300.[8]

Production

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PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found here.

Clinical significance

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PROX1 is used as a marker for lymphatic endothelium in biopsy samples.

Homologous gene

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PROX2

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117707Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010175Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zinovieva RD, Duncan MK, Johnson TR, Torres R, Polymeropoulos MH, Tomarev SI (Dec 1996). "Structure and chromosomal localization of the human homeobox gene Prox 1". Genomics. 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID 8812486.
  6. ^ "Entrez Gene: PROX1 prospero-related homeobox 1".
  7. ^ Harvey, Natasha L (October 2005). "Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity". Nature Genetics. 37 (10): 1072–1081. doi:10.1038/ng1642. PMID 16170315. S2CID 25103068.
  8. ^ Chen, Qin; Dowhan Dennis H; Liang Dongcai; Moore David D; Overbeek Paul A (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. 277 (27). United States: 24081–9. doi:10.1074/jbc.M201821200. ISSN 0021-9258. PMID 11943779.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.