Bernardo is a surname. Notable people with the surname include:
- Bernardo Bernardo (1941–2018), Filipino veteran stage actor, comedian, and film director
- José-Miguel Bernardo, Spanish statistician
- Joseph Bernardo (born 1929), French swimmer
- Kathryn Bernardo (born 1996), Filipina actress
- Mariano Bernardo (born 1988), Brazilian footballer
- Mike Bernardo (1969–2012), South African kickboxer and boxer
- Noah Bernardo (born 1972), drummer and a founding member of the San Diego–based band P.O.D.
- Paul Bernardo (born 1964), Canadian serial killer and rapist
- Samantha Bernardo (born 1992), Filipina beauty pageant titleholder, Binibining Pilipinas Grand International 2020, and 1st runner up Miss Grand International 2020