Bettoni is an Italian surname. Notable people with the surname include:
- Count Lorenzo Bettoni ennobled in 1684 in Venice, Italy
- Count Francesco Bettoni Cazzago (1835–1898), writer and professor at the University of Padua, Italy.
- Count Federico Bettoni Cazzago (1865–1923), President of the Italian Red Cross
- Count Alessandro Bettoni Cazaggo (1892–1951), a rider and military career, in part in Olympic Games of London in 1948
- David Bettoni (born 1971), French former professional football player and coach
- Eduardo Bettoni (born 1990), Brazilian judoka
- Patrick Bettoni (born 1975), Swiss–Italian footballer
- Samuele Bettoni (born 1989), Italian footballer
- Vincenzo Bettoni (1881–1954), Italian opera singer