Bexlosteride

Bexlosteride
Clinical data
Other names	LY 300502
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name (4aR,10bR)-8-Chloro-4-methyl-1,4,4a,5,6,10b-hexahydrobenzo[f]quinolin-3(2H)-one;
CAS Number	148905-78-6 ;
PubChem CID	166562;
ChemSpider	145762 ;
UNII	36X732P4P0;
ChEMBL	ChEMBL24955 ;
Chemical and physical data
Formula	C14H16ClNO
Molar mass	249.74 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1[C@@H]2CCc3cc(ccc3[C@H]2CCC1=O)Cl;
	InChI InChI=1S/C14H16ClNO/c1-16-13-6-2-9-8-10(15)3-4-11(9)12(13)5-7-14(16)17/h3-4,8,12-13H,2,5-7H2,1H3/t12-,13-/m1/s1 ; Key:WQBIOEFDDDEARX-CHWSQXEVSA-N ;
	(what is this?) (verify)

Bexlosteride is a potent and noncompetitive inhibitor of the enzyme 5α-reductase related to finasteride and dutasteride.^[1]^[2] It is selective for the type I isoform of the enzyme.^[1] It advanced to Phase III clinical trials, but development was halted at that stage, and it was never marketed.^[3]^[4]

References

Clinical data

Other names	LY 300502
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name (4aR,10bR)-8-Chloro-4-methyl-1,4,4a,5,6,10b-hexahydrobenzo[f]quinolin-3(2H)-one
CAS Number	148905-78-6^N
PubChem CID	166562
ChemSpider	145762^Y
UNII	36X732P4P0
ChEMBL	ChEMBL24955^Y
Chemical and physical data
Formula	C₁₄H₁₆ClNO
Molar mass	249.74 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN1[C@@H]2CCc3cc(ccc3[C@H]2CCC1=O)Cl
InChI InChI=1S/C14H16ClNO/c1-16-13-6-2-9-8-10(15)3-4-11(9)12(13)5-7-14(16)17/h3-4,8,12-13H,2,5-7H2,1H3/t12-,13-/m1/s1^Y Key:WQBIOEFDDDEARX-CHWSQXEVSA-N^Y
^NY (what is this?) (verify)