The bglG cis regulatory RNA was identified by RNA deep sequencing of Clostridioides difficile 630 [1] where it is located immediately upstream of gene bglG2. BglG2 is an antiterminator protein involved in the regulation of genes of the Beta-glucoside phosphotransferase system in.[2] Homologues of the C. difficile element were found across Clostridiales and other Bacillota. The element is consistently located 5’ of bglG2 or LicT, another antiterminator of the Beta-Glucoside Phosphotransferase System [2], consistent with a cis-regularly function at these operons. Only Clostridiales sequences were included in the seed alignment. Sequence is named S0591 in ref.[1]
| bglG-cis-reg | |
|---|---|
 Consensus secondary structure and sequence conservation of cis-regulatory element of the bglG/LicT operon | |
| Identifiers | |
| Symbol | bglG-cis-reg |
| Rfam | RF03530 |
| Other data | |
| RNA type | Cis-reg |
| SO | SO:0005836 |
| PDB structures | PDBe |
References
edit- ^ a b Soutourina OA, Monot M, Boudry P, Saujet L, Pichon C, Sismeiro O; et al. (2013). "Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile". PLOS Genet. 9 (5): e1003493. doi:10.1371/journal.pgen.1003493. PMC 3649979. PMID 23675309.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Tanaka Y, Teramoto H, Inui M, Yukawa H (2011). "Translation efficiency of antiterminator proteins is a determinant for the difference in glucose repression of two β-glucoside phosphotransferase system gene clusters in Corynebacterium glutamicum R." J Bacteriol. 193 (2): 349–57. doi:10.1128/JB.01123-10. PMC 3019825. PMID 21075922.
{{cite journal}}: CS1 maint: multiple names: authors list (link)