The bglG cis regulatory RNA was identified by RNA deep sequencing of Clostridioides difficile 630 [1] where it is located immediately upstream of gene bglG2. BglG2 is an antiterminator protein involved in the regulation of genes of the Beta-glucoside phosphotransferase system in.[2] Homologues of the C. difficile element were found across Clostridiales and other Bacillota. The element is consistently located 5’ of bglG2 or LicT, another antiterminator of the Beta-Glucoside Phosphotransferase System [2], consistent with a cis-regularly function at these operons. Only Clostridiales sequences were included in the seed alignment. Sequence is named S0591 in ref.[1]
bglG-cis-reg | |
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![]() Consensus secondary structure and sequence conservation of cis-regulatory element of the bglG/LicT operon | |
Identifiers | |
Symbol | bglG-cis-reg |
Rfam | RF03530 |
Other data | |
RNA type | Cis-reg |
SO | SO:0005836 |
PDB structures | PDBe |
References
edit- ^ a b Soutourina OA, Monot M, Boudry P, Saujet L, Pichon C, Sismeiro O; et al. (2013). "Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile". PLOS Genet. 9 (5): e1003493. doi:10.1371/journal.pgen.1003493. PMC 3649979. PMID 23675309.
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: CS1 maint: multiple names: authors list (link) - ^ Tanaka Y, Teramoto H, Inui M, Yukawa H (2011). "Translation efficiency of antiterminator proteins is a determinant for the difference in glucose repression of two β-glucoside phosphotransferase system gene clusters in Corynebacterium glutamicum R." J Bacteriol. 193 (2): 349–57. doi:10.1128/JB.01123-10. PMC 3019825. PMID 21075922.
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: CS1 maint: multiple names: authors list (link)