Bile-acid 7alpha-dehydroxylase (EC 1.17.99.5, cholate 7alpha-dehydroxylase, 7alpha-dehydroxylase, bile acid 7-dehydroxylase) was thought to be an enzyme with systematic name deoxycholate:NAD+ oxidoreductase.[1][2][3][4]
| Bile-acid 7alpha-dehydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.17.99.5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
However, it was later shown that the dehydroxylation is carried out by seven different enzymes, catalyzing a total of 8 reactions. The enzymes are EC 6.2.1.7, EC 1.1.1.395, EC 1.3.1.115, EC 2.8.3.25, EC 4.2.1.106, EC 1.3.1.114, and EC 1.1.1.52.
References
edit- ^ White BA, Cacciapuoti AF, Fricke RJ, Whitehead TR, Mosbach EH, Hylemon PB (August 1981). "Cofactor requirements for 7 alpha-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 13708". Journal of Lipid Research. 22 (6): 891–8. PMID 7276750.
- ^ White BA, Paone DA, Cacciapuoti AF, Fricke RJ, Mosbach EH, Hylemon PB (January 1983). "Regulation of bile acid 7-dehydroxylase activity by NAD+ and NADH in cell extracts of Eubacterium species V.P.I. 12708". Journal of Lipid Research. 24 (1): 20–7. PMID 6833878.
- ^ Coleman JP, White WB, Hylemon PB (April 1987). "Molecular cloning of bile acid 7-dehydroxylase from Eubacterium sp. strain VPI 12708". Journal of Bacteriology. 169 (4): 1516–21. PMC 211977. PMID 3549693.
- ^ Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
External links
edit- Bile-acid+7alpha-dehydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
