Bile salt sulfotransferase

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.[5][6][7]

SULT2A1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesSULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa, sulfotransferase family 2A member 1, DHEA-ST8, SULT2A3
External IDsOMIM: 125263; MGI: 3645854; HomoloGene: 37741; GeneCards: SULT2A1; OMA:SULT2A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003167

NM_001101534

RefSeq (protein)

NP_003158

n/a

Location (UCSC)Chr 19: 47.87 – 47.89 MbChr 7: 13.64 – 13.72 Mb
PubMed search[3][4]
Wikidata
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Function

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Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfonates steroids and bile acids.[5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105398Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074377Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1".
  6. ^ Otterness DM, Wieben ED, Wood TC, Watson WG, Madden BJ, McCormick DJ, Weinshilboum RM (May 1992). "Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA". Mol. Pharmacol. 41 (5): 865–72. PMID 1588921.
  7. ^ Otterness DM, Mohrenweiser HW, Brandriff BF, Weinshilboum RM (1995). "Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3". Cytogenet. Cell Genet. 70 (1–2): 45–7. doi:10.1159/000133988. PMID 7736787.

Further reading

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