Biliverdin reductase A

Biliverdin reductase A is a protein that in humans is encoded by the BLVRA gene.[5][6]

biliverdin reductase A
Biliverdin reductase A dimer, Human
Identifiers
EC no.1.3.1.24
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
BLVRA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBLVRA, BLVR, BVR, BVRA, biliverdin reductase A
External IDsOMIM: 109750; MGI: 88170; HomoloGene: 572; GeneCards: BLVRA; OMA:BLVRA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000712
NM_001253823

NM_026678

RefSeq (protein)

NP_000703
NP_001240752

NP_080954

Location (UCSC)Chr 7: 43.76 – 43.81 MbChr 2: 126.91 – 126.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH.[5]

Clinical significance

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Mutations in this gene are associated with hyperbiliverdinemia.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106605Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001999Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "Entrez Gene: Biliverdin reductase A".
  6. ^ Schomburg D, Schomburg I, Chang A (2004). Class 1 Oxidoreductases V. Springer Handbook of Enzymes. Vol. 21 (2nd ed.). Springer Science & Business Media. pp. 140–. ISBN 978-3-540-22515-7.
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  • Human BLVRA genome location and BLVRA gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Biliverdin reductase A

This article incorporates text from the United States National Library of Medicine, which is in the public domain.