Binospirone

Binospirone
Clinical data
ATC code	none;
Identifiers
	IUPAC name 8-[2-(2,3-dihydro-1,4-benzodioxin-2-ylmethylamino)ethyl]-8-azaspiro[4.5]decane-7,9-dione;
CAS Number	102908-59-8 ; mesylate: 124756-23-6 ;
PubChem CID	60769;
ChemSpider	54766;
UNII	T3M5D109V5; mesylate: 155R3B9K8H ;
ChEMBL	ChEMBL1487115;
CompTox Dashboard (EPA)	DTXSID50861284 ;
Chemical and physical data
Formula	C20H26N2O4
Molar mass	358.438 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1N(C(=O)CC2(C1)CCCC2)CCNCC3Oc4ccccc4OC3;
	InChI InChI=1S/C20H26N2O4/c23-18-11-20(7-3-4-8-20)12-19(24)22(18)10-9-21-13-15-14-25-16-5-1-2-6-17(16)26-15/h1-2,5-6,15,21H,3-4,7-14H2; Key:BVMYCHKQPGEOSI-UHFFFAOYSA-N;
	(verify)

Binospirone (MDL-73,005-EF) is a drug which acts as a partial agonist at 5-HT_1A somatodendritic autoreceptors but as an antagonist at postsynaptic 5-HT_1A receptors.^[1] It has anxiolytic effects.^[2]

References

^ Bertrand F, Lehmann O, Galani R, Lazarus C, Jeltsch H, Cassel JC (April 2001). "Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats". Pharmacology, Biochemistry, and Behavior. 68 (4): 647–60. doi:10.1016/S0091-3057(01)00448-8. PMID 11526961. S2CID 8595441.
^ Moser PC, Tricklebank MD, Middlemiss DN, Mir AK, Hibert MF, Fozard JR (February 1990). "Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam". British Journal of Pharmacology. 99 (2): 343–9. doi:10.1111/j.1476-5381.1990.tb14706.x. PMC 1917389. PMID 1970269.

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[1] Bertrand F, Lehmann O, Galani R, Lazarus C, Jeltsch H, Cassel JC (April 2001). "Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats". Pharmacology, Biochemistry, and Behavior. 68 (4): 647–60. doi:10.1016/S0091-3057(01)00448-8. PMID 11526961. S2CID 8595441.

[2] Moser PC, Tricklebank MD, Middlemiss DN, Mir AK, Hibert MF, Fozard JR (February 1990). "Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam". British Journal of Pharmacology. 99 (2): 343–9. doi:10.1111/j.1476-5381.1990.tb14706.x. PMC 1917389. PMID 1970269.

[1]

[2]

Clinical data


ATC code	none
Identifiers
IUPAC name 8-[2-(2,3-dihydro-1,4-benzodioxin-2-ylmethylamino)ethyl]-8-azaspiro[4.5]decane-7,9-dione
CAS Number	102908-59-8^Y mesylate: 124756-23-6^Y
PubChem CID	60769
ChemSpider	54766
UNII	T3M5D109V5 mesylate: 155R3B9K8H^Y
ChEMBL	ChEMBL1487115
CompTox Dashboard (EPA)	DTXSID50861284
Chemical and physical data
Formula	C₂₀H₂₆N₂O₄
Molar mass	358.438 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C1N(C(=O)CC2(C1)CCCC2)CCNCC3Oc4ccccc4OC3
InChI InChI=1S/C20H26N2O4/c23-18-11-20(7-3-4-8-20)12-19(24)22(18)10-9-21-13-15-14-25-16-5-1-2-6-17(16)26-15/h1-2,5-6,15,21H,3-4,7-14H2 Key:BVMYCHKQPGEOSI-UHFFFAOYSA-N
(verify)

Binospirone

See also

References